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ONX-0914
CAS No. 960374-59-8
ONX-0914 ( PR-957 | ONX 0914 | ONX0914 | PR957 | PR 957 )
产品货号. M16857 CAS No. 960374-59-8
ONX-0914 (PR-957) 是一种有效的、选择性的免疫蛋白酶体 LMP7 胰凝乳蛋白酶样亚基抑制剂，IC80 <100 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥988 | 有现货 |
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| 10MG | ￥1596 | 有现货 |
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| 25MG | ￥2689 | 有现货 |
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| 50MG | ￥4034 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称ONX-0914
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述ONX-0914 (PR-957) 是一种有效的、选择性的免疫蛋白酶体 LMP7 胰凝乳蛋白酶样亚基抑制剂，IC80 <100 nM。
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产品描述ONX-0914 (PR-957) is a potent, selective inhibitor of the chymotrypsin-like subunit of immunoproteasome LMP7 with IC80 <100 nM, 20- to 40-fold more selective over β5 or LMP2; blocks presentation of LMP7-specific, MHC-I-restricted antigens in vitro and in vivo, blocks production of interleukin-23 (IL-23) by activated monocytes and interferon-gamma and IL-2 by T cells; reverses signs of disease and results in reductions in cellular infiltration, cytokine production and autoantibody levels in experimental arthritis models.
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体外实验——
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体内实验Animal Model:Collagen antibody-induced arthritis (CAIA, Arthritis was induced in BALB/c mice with antibodies specific for type II collagen (mAb) and endotoxin)Dosage:2, 6 or 10 mg per kg body weight Administration:I.v.; treated on days 4, 6 and 8 Result:Blocked disease progression in a dose-dependent manner and completely ameliorated visible signs of disease at the highest dose.
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同义词PR-957 | ONX 0914 | ONX0914 | PR957 | PR 957
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通路Proteasome/Ubiquitin
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靶点Proteasome
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受体LMP7
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研究领域Inflammation/Immunology
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适应症——
化学信息
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CAS Number960374-59-8
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分子量580.6719
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分子式C31H40N4O7
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 35 mg/mL
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SMILESO=C(N[C@@H](CC1=CC=CC=C1)C([C@]2(C)OC2)=O)[C@@H](NC([C@@H](NC(CN3CCOCC3)=O)C)=O)CC4=CC=C(OC)C=C4
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化学全称L-Tyrosinamide, N-[2-(4-morpholinyl)acetyl]-L-alanyl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Muchamuel T, et al. Nat Med. 2009 Jul;15(7):781-7.
2. Basler M, et al. J Immunol. 2010 Jul 1;185(1):634-41.
3. Ichikawa HT, et al. Arthritis Rheum. 2012 Feb;64(2):493-503.
4. Verbrugge SE, et al. J Pharmacol Exp Ther. 2012 Apr;341(1):174-82.
