ONO-RS-082

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ONO-RS-082 是一种不依赖 Ca2+ 的磷脂酶 A2 抑制剂。

ONO-RS-082 is a Ca2+-independent phospholipase A2 inhibitor.?(In Vitro):ONO-RS-082 at 3.5 μM was able to inhibit epinephrine-stimulated thromboxane production in human platelets.?ONO-RS-082 could also disrupt endosome tubule formation and maintenance of the Golgi complex.

Cell Viability Assay Cell Line:A549 lung epithelial cell lines Concentration:10 μM Incubation Time:2-h pretreatment Result:Completely blocked HXA3-mediated PAO1-induced PMN transepithelial migration. Largely prevented PAO1-induced PGE2 release.

Animal Model:MCT- pulmonary hypertension (PH) rat model Dosage:50 mg/kg/day Administration:Result:Reduced the development of PH in the MCT-PH model for long-term.

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Others

Other Targets

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99754-06-0

371.86

C21H22ClNO3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (268.92 mM)

CCCCCc1ccc(\C=C\C(=O)Nc2cc(Cl)ccc2C(O)=O)cc1

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(-20℃)

With Ice Pack

≥ 2 years