OGG1-IN-O8

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

OGG1-IN-O8 是 8-氧代鸟嘌呤 DNA 糖基化酶 1 的抑制剂 (OGG1;IC50 : 0.35 μM)。

OGG1-IN-O8 is an inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1;IC50 : 0.35 μM).

OGG1-IN-08 (50 μM) inhibits different DNA glycosylases activities, it inhibits?nei endonuclease VIII-like 1 DNA glycosylase (NEIL1)(84.56%), endonuclease III-like (NTH1)(63.09%), andFpg (91.74%), respectively.OGG1-IN-08 (10 μM) has a inhibitory OGG1 lyase activity on a substrate containing an AP site compared with the no inhibitor control.OGG1-IN-08 (10 μM) decreases the number of bases released into solution by OGG1 for both the 8-oxo-Gua and FapyGua compared with the no inhibitor.

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Others

Other Targets

8-oxoguanine DNA glycosylase 1 (OGG1)

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350997-39-6

261.12

C9H6Cl2N2OS

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (95.74 mM)

NNC(=O)c1sc2cccc(Cl)c2c1Cl

34-Dichloro-benzo[b]thiophene-2-carboxylic acid hydrazide

(-20℃)

With Ice Pack

≥ 2 years