OAC1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

OAC1 是一种八聚体结合转录因子 4 (Oct4) 激活化合物；提高 iPSC 重编程效率并加速重编程过程。

OAC1 is a Octamer-binding transcription factor 4 (Oct4)-activating compound; enhances the iPSC reprogramming efficiency and accelerated the reprogramming process.

OAC1 (10 μM; 7 d) enhances reprogramming efficiency. OAC1 increases induced pluripotent stem cells (iPSC) generation from mouse embryonic fibroblasts (MEFs) and accelerates the appearance of iPSC-like colonies. OAC1 (1 μM; 2 d; human IMR90 fibroblast cells) activates endogenous Oct4, Nanog, Sox2, and Tet1 expression.OAC1 (500 nM; 4 d; CD34+ cells) increases numbers of phenotypic hematopoietic stem cells (HSC) and functional Hematopoietic progenitor cells (HPC).OAC1 (500 nM; 4 d; CD34+ cells) activates OCT4 through upregulation of HOXB4 expression to expand hematopoietic stem cells (HSC). Cell Proliferation Assay Cell Line:CD34+ cells from human cord blood Concentration:500 nMIncubation Time:4 days Result:Increased the numbers of CD34+CD38- cells.Increased the number of Lin-CD34+CD38-CD45RA-CD90+CD49f+ cells.Increased in the number of phenotypic hematopoietic stem cells (HSC) compared to control vectors.Enhanced expansion of HPC with both full and suboptimal cytokine doses in the expansion and colony forming phases.

OAC1 (50000 CB CD34+ cells with OAC1(500 nM); i.h.; 16 weeks) enhances short and long-term engrafting hematopoietic stem cells (HSC) in irradiated NSG mice. Animal Model:Irradiated NSG mice with OAC1 or vehicle control treated CB CD34+ cells within 24h after irradiation Dosage:16 weeks Administration:Subcutaneous injection OAC1(500 nM) treated CB CD34+ cells Result:Increased cord blood (CB) cells in primary recipients, compared to the vehicle control group, with the board increase for human B cells, T cells, and myeloid cells in the bone marrow (BM) of primary recipients, resulting in a significant expansion of SRC numbers.

OAC 1 | OAC1 | OAC-1

Membrane Transporter/Ion Channel

OCT

OCT4

Other Indications

——

300586-90-7

237.26

C14H11N3O

>98% (HPLC)

Ethanol: 21 mg/mL (88.51 mM); DMSO: 47 mg/mL (198.09 mM)

O=C(NC1=CC2=C(NC=C2)C=N1)C3=CC=CC=C3

N-(1H-pyrrolo[2,3-c]pyridin-5-yl)benzamide

(-20℃)

With Ice Pack

≥ 2 years