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Novobiocin

CAS No. 303-81-1

Novobiocin ( —— )

产品货号. M33676 CAS No. 303-81-1

Novobiocin (Albamycin) 是一种有效且具有口服活性的抗生素。Novobiocin 还是 DNA 促旋酶抑制剂和热休克蛋白 90 (Hsp90) 拮抗剂。Novobiocin 具有研究高度耐药性肺炎球菌感染的潜力. Novobiocin 具有抗正痘活性[ 4]。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥452 有现货
10MG ¥654 有现货
25MG ¥1040 有现货
50MG ¥1548 有现货
100MG ¥2241 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Novobiocin
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Novobiocin (Albamycin) 是一种有效且具有口服活性的抗生素。Novobiocin 还是 DNA 促旋酶抑制剂和热休克蛋白 90 (Hsp90) 拮抗剂。Novobiocin 具有研究高度耐药性肺炎球菌感染的潜力. Novobiocin 具有抗正痘活性[ 4]。
  • 产品描述
    Novobiocin (Albamycin) is a potent and orally active antibiotic. Novobiocin also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin shows anti-orthopoxvirus activity.
  • 体外实验
    Novobiocin (1 mM) competitively inhibits ATP binding to gyrase B to interfere with nucleotide binding and interferes with the association of the co-chaperones Hsc70 and p23 with Hsp90.Novobiocin (200 μM; 24 h) inhibits the rate of repair of both cis-DDP and BCNU induced DNA interstrand cross-links and with a corresponding decrease in the clonogenic survival of the human glioblastoma multiforme cells.Novobiocin (0.3 mM; 48 hours) induces a caspase-3/7 enzyme–dependent apoptosis assays with an induction of approximately three- to fivefold of apoptotic cells in K562, HL60, Mutz-2.
  • 体内实验
    Novobiocin (25, 50, 100, 200 mg/kg; s.c.; 4 times at 1, 5, 24 and 48 h after infection) shows anti-infection activity in mice infected with amoxicillin-resistant Streptococcus pneumoniae.Animal Model:30 g adult female Swiss mice (sepsis induced by the penicillin-susceptible strain (AR33118))Dosage:25, 50, 100, 200 mg/kg Administration:S.c.; given at 1, 5, 24 and 48 h after infection Result:Showed anti-infection activity in mice infected with amoxicillin-resistant S. pneumoniae.
  • 同义词
    ——
  • 通路
    Cell Cycle/DNA Damage
  • 靶点
    DNA gyrase
  • 受体
    DNA gyrase | Antibacterial | HSP | Apoptosis | Virus Protease | Antibiotic
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    303-81-1
  • 分子量
    612.62
  • 分子式
    C31H36N2O11
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    CO[C@@H]1[C@@H](OC(N)=O)[C@@H](O)[C@H](Oc2ccc3c(O)c(NC(=O)c4ccc(O)c(CC=C(C)C)c4)c(=O)oc3c2C)OC1(C)C
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Marcu MG, et al. The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone. J Biol Chem. 2000 Nov 24;275(47):37181-6.?
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