
Novobiocin
CAS No. 303-81-1
Novobiocin ( —— )
产品货号. M33676 CAS No. 303-81-1
Novobiocin (Albamycin) 是一种有效且具有口服活性的抗生素。Novobiocin 还是 DNA 促旋酶抑制剂和热休克蛋白 90 (Hsp90) 拮抗剂。Novobiocin 具有研究高度耐药性肺炎球菌感染的潜力. Novobiocin 具有抗正痘活性[ 4]。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥452 | 有现货 |
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10MG | ¥654 | 有现货 |
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25MG | ¥1040 | 有现货 |
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50MG | ¥1548 | 有现货 |
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100MG | ¥2241 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Novobiocin
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Novobiocin (Albamycin) 是一种有效且具有口服活性的抗生素。Novobiocin 还是 DNA 促旋酶抑制剂和热休克蛋白 90 (Hsp90) 拮抗剂。Novobiocin 具有研究高度耐药性肺炎球菌感染的潜力. Novobiocin 具有抗正痘活性[ 4]。
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产品描述Novobiocin (Albamycin) is a potent and orally active antibiotic. Novobiocin also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin shows anti-orthopoxvirus activity.
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体外实验Novobiocin (1 mM) competitively inhibits ATP binding to gyrase B to interfere with nucleotide binding and interferes with the association of the co-chaperones Hsc70 and p23 with Hsp90.Novobiocin (200 μM; 24 h) inhibits the rate of repair of both cis-DDP and BCNU induced DNA interstrand cross-links and with a corresponding decrease in the clonogenic survival of the human glioblastoma multiforme cells.Novobiocin (0.3 mM; 48 hours) induces a caspase-3/7 enzyme–dependent apoptosis assays with an induction of approximately three- to fivefold of apoptotic cells in K562, HL60, Mutz-2.
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体内实验Novobiocin (25, 50, 100, 200 mg/kg; s.c.; 4 times at 1, 5, 24 and 48 h after infection) shows anti-infection activity in mice infected with amoxicillin-resistant Streptococcus pneumoniae.Animal Model:30 g adult female Swiss mice (sepsis induced by the penicillin-susceptible strain (AR33118))Dosage:25, 50, 100, 200 mg/kg Administration:S.c.; given at 1, 5, 24 and 48 h after infection Result:Showed anti-infection activity in mice infected with amoxicillin-resistant S. pneumoniae.
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同义词——
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通路Cell Cycle/DNA Damage
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靶点DNA gyrase
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受体DNA gyrase | Antibacterial | HSP | Apoptosis | Virus Protease | Antibiotic
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研究领域——
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适应症——
化学信息
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CAS Number303-81-1
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分子量612.62
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分子式C31H36N2O11
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纯度>98% (HPLC)
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溶解度——
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SMILESCO[C@@H]1[C@@H](OC(N)=O)[C@@H](O)[C@H](Oc2ccc3c(O)c(NC(=O)c4ccc(O)c(CC=C(C)C)c4)c(=O)oc3c2C)OC1(C)C
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Marcu MG, et al. The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone. J Biol Chem. 2000 Nov 24;275(47):37181-6.?
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