Noopept

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

奥贝西坦是一种合成二肽，已被证明通过与其他相关消旋化合物类似的机制在动物模型中产生积极的促智和认知作用。

Omberacetam is a synthetic dipeptide that has been shown to produce positive nootropic and cognitive effects in animal models by a mechanism similar to other related racetam compounds.

Nooglutil exhibits pharmacologically significant competition with a selective agonist of AMPA receptors ([G-3H]Ro 48-8587) for the receptor binding sites (with IC50 = 6.4 +/- 0.2 microM), while the competition of noopept for these receptor binding sites was lower by an order of magnitude (IC50 = 80 +/- 5.6 microM) . GVS-111 significantly increased neuronal survival after H(2)O(2)-treatment displaying a dose-dependent neuroprotective activity from 10 nM to 100 microM, and an IC(50) value of 1.21+/-0.07 microM. GVS-111 inhibited the accumulation of intracellular free radicals and lipid peroxidation damage in neurons treated with H(2)O(2) or FeSO(4), suggesting an antioxidant mechanism of action .

N-Phenylacetyl-L-prolylglycine ethyl ester (GVS-111) administered intravenously at a dose of 0.5 mg/kg/day, for the first time 1 h after ischaemic lesion and then for 9 post-operative days, with the last administration 15 min before testing, attenuated the deficit . GVS-111 itself was not found in rat brain 1 h after 5 mg/kg i.p. administration up to limit of detection (LOD) under high performance liquid chromatography (HPLC) conditions . The most pronounced antiinflammatory effect of dipeptide was observed on the model of adjuvant arthritis in rats, where the drug administered over 25 days in a daily dose of 0.5 mg/kg (i.m.) or 5 mg/kg (p.o.) significantly reduced the chronic immune inflammation (on the 12th day, by 94.0 and 74.1%, respectively) .

Omberacetam | GVS-111 | SGS-111

Others

Other Targets

Others

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157115-85-0

318.37

C17H22N2O4

>98% (HPLC)

DMSO:100 mg/mL (314.10 mM)

CCOC(=O)CNC(=O)[C@@H]1CCCN1C(=O)Cc1ccccc1

ethyl (2-phenylacetyl)-L-prolylglycinate

(-20℃)

With Ice Pack

≥ 2 years