Nitroxoline

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Nitroxoline 是一种泌尿系抗菌剂，可有效对抗尿路感染中常见的敏感革兰氏阳性和革兰氏阴性微生物。

Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. It is a fluorquinolone that is active against bacterial gyrases.

Cell Viability Assay Cell Line:H446, H1882, H1417, and H1688 cells Concentration:2.5 μM, 5 μM, 10 μM, 20 μM Incubation Time:24 hours Result:Effectively inhibit cell survival of small-cell lung cancer (SCLC) cells.Western Blot Analysis Cell Line:H446, H1882, H1417 cells Concentration:5 μM, 10 μM, 20 μM Incubation Time:24 hours Result:Suppressed antiapoptotic proteins (such as Bcl-2 and MCL1) and upregulated proapoptotic protein Bim.

Animal Model:C3H/He mice bladder injected with MBT-2 cells Dosage:15 mg/kg or 60mg/kg Administration:Orally gavage; five times a week on days 1, 2, 4, 5, 7, 8, 10, and 11.Result:Resulted in significant inhibition of tumor growth.

Nitroxoline, 5-nitrox, 5-NOK, Cysto-saar plus, Nibiol

Others

Other Targets

Fe2+/Zn2+ ions

Infection

——

4008-48-4

190.16

C9H6N2O3

>98% (HPLC)

Water: 2.73 g/L

OC1=C2C(C=CC=N2)=C([N+]([O-])=O)C=C1

5-nitroquinolin-8-ol

(-20℃)

With Ice Pack

≥ 2 years