Nitrosoglutathione

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

GSNO 是一种内源性转亚硝化供体，参与多种细胞蛋白质的 S-亚硝化。 GSNO 是一种外源性 NO 供体和大鼠乙醇脱氢酶 III 类同工酶的底物，可抑制脑血管紧张素 II 依赖性和非依赖性 AT1 受体反应。

GSNO is an endogenous transnitrosation donor involved in S-nitrosation of a variety of cellular proteins. GSNO, an exogenous NO donor and substrate of rat alcohol dehydrogenase class III isoenzyme, inhibits cerebral angiotensin II-dependent and -independent AT1 receptor responses.(In Vitro):GSNO completely abolished the AngII-dependent AT1 receptor-mediated vasoconstriction of cerebral arteries. GSNO had no impact on responses to other vasoconstrictors sharing (phenylephrine, U46619) or not (5-HT) the same signalling pathway. (In Vivo):Elevated blood pressure, proteinuria, and intrauterine growth restriction associated with PE were induced in Sprague-Dawley rats using L-NAME. These were partially reversed with the use of GSNO.

Nitrosoglutathione (GSNO, 250 μM) prevents 90% of the response to 0.1 μM 5-HT and 40% of the response to 1.0 μM 5-HT in rings treated with LY-83583, indicating an effect of GSNO that was independent of guanylate cyclase activity.

Nitrosoglutathione (GSNO, 8 mg/kg) significantly decreases systolic, diastolic, and mean arterial pressures in PE-induced rats from day 14 through day 20.Nitrosoglutathione (GSNO, 0.2 and 0.6 mg/kg) significantly inhibits superoxide production and suppressed NF-κB activation, iNOS induction, and 3-nitrotyrosine expression, but up-regulates endothelial NOS expression in the flap vessels. Animal Model:Male Lewis rats.Dosage:0.2 and 0.6 mg/kg.Administration:Slow intravenous injection via the opposite femoral vein into each rat.Result:Animals treated with 0.2 mg of GSNO per kilogram before reperfusion had an intermediate survival rate (40.2 ± 4.9%). Although 0.6 mg/kg of GSNO showed a better rescuing effect than 150 mg/kg of NAC, there was no significant difference between the groups.

GSNO | SNOG | S-Nitrosoglutathione | Glutathione thionitrite

Endocrinology/Hormones

RAAS

PI3Kδ

——

——

57564-91-7

336.32

C10H16N4O7S

>98% (HPLC)

In Vitro:?H2O : 25 mg/mL (74.33 mM)

N[C@@H](CCC(=O)N[C@@H](CSN=O)C(=O)NCC(O)=O)C(O)=O

——

(-20℃)

With Ice Pack

≥ 2 years