Nitecapone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Nitecapone 是 S-COMT 的可逆抑制剂（在大鼠肝脏中的 IC50 值为 300 nM）。

Nitecapone is a reversible inhibitor of S-COMT (IC50 values of 300 nM in rat liver).

Nitecapone (1-100 μM) reducesd GSH (reduced glutathione) depletion induced by ROO-by 11-38% and oxidation to oxidized glutathione (GSSG) by 32-45%.

Nitecapone (30 mg/kg, ip daily for 13 days) reduces development and symptoms of neuropathic pain after spinal nerve ligation in rats. Animal Model:Eighty-six male Wistar rats, weighing 140-350 g.Dosage:30 mg/kg (3.3 mL/kg).Administration:IP, once daily for 13 days.Result:Selectively and specifically inhibits COMT in the peripheral tissues, and to some extent in the CNS for ca. 3 h.Increased the thresholds for the mechanical stimuli and thus reduced mechanical allodynia.Reduced the number of positive reactions of the ipsilateral paws when compared with the baselines in the nitecapone-pretreated rats.

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Others

Other Targets

S-COMT

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116313-94-1

265.22

C12H11NO6

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (188.52 mM)

CC(=O)C(=Cc1cc(O)c(O)c([N+](=O)[O-])c1)C(C)=O

3-(34-Dihydroxy-5-nitrobenzylidene)-24-pentanedione

(-20℃)

With Ice Pack

≥ 2 years