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Nedocromil
CAS No. 69049-73-6
Nedocromil ( FPL 59002 | FPL59002 )
产品货号. M15644 CAS No. 69049-73-6
Nedocromil (FPL59002) 是一种肥大细胞稳定剂，抑制肥大细胞脱颗粒，防止组胺和类胰蛋白酶的释放。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥518 | 有现货 |
|
| 10MG | ￥786 | 有现货 |
|
| 25MG | ￥1725 | 有现货 |
|
| 50MG | ￥2811 | 有现货 |
|
| 100MG | ￥4431 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Nedocromil
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Nedocromil (FPL59002) 是一种肥大细胞稳定剂，抑制肥大细胞脱颗粒，防止组胺和类胰蛋白酶的释放。
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产品描述Nedocromil (FPL59002) is a mast cell stabilizer, inhibits the degranulation of mast cells, prevents release of histamine and tryptase, so preventing the synthesis of prostaglandins and leukotrienes.Allergy Approved.
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体外实验Nedocromil inhibits the release of histamine, LTC4, and PGD2 from mast cells challenged with antigen (with IC30 values of 2.1 μM, 2.3 μM, and 1.9 μM, respectively) and with anti-human IgE (IC30 values of 4.7 μM, 1.3 μM, and 1.3 μM, respectively).
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体内实验Nedocromil-treated diabetic mice show significantly improved heart function compared with controls. The contractility and relaxation forces show similar improvements. However, the cardiac function of Nedocromil-treated diabetic mice remains significantly impaired when compared with normal mice. Nedocromil can significantly improve cardiac function in mice with diabetic cardiomyopathy, but the treatment cannot restore normal function.
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同义词FPL 59002 | FPL59002
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通路GPCR/G Protein
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靶点Leukotriene Receptor
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受体Leukotriene Receptor
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研究领域Inflammation/Immunology
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适应症Allergy
化学信息
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CAS Number69049-73-6
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分子量371.3408
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分子式C19H17NO7
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纯度>98% (HPLC)
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溶解度DMSO: 15 mg/mL
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SMILESO=C(C1=CC(C2=CC3=C(N(CC)C(C(O)=O)=CC3=O)C(CCC)=C2O1)=O)O
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化学全称4H-Pyrano[3,2-g]quinoline-2,8-dicarboxylic acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Lal S, et al. Thorax. 1984 Nov;39(11):809-12.
2. Eady RP, et al. Br J Pharmacol. 1985 Jun;85(2):323-5.
3. Cairns H, et al. J Med Chem. 1985 Dec;28(12):1832-42.
产品手册
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