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Nateglinide

CAS No. 105816-04-4

Nateglinide ( A-4166 | SDZ-DJN 608 )

产品货号. M10264 CAS No. 105816-04-4

那格列奈是一种口服降血糖药,用于治疗非胰岛素依赖型糖尿病(NIDDM)。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
10MG ¥332 有现货
25MG ¥672 有现货
50MG ¥1199 有现货
100MG ¥2017 有现货
200MG ¥2908 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Nateglinide
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    那格列奈是一种口服降血糖药,用于治疗非胰岛素依赖型糖尿病(NIDDM)。
  • 产品描述
    Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that induces an early insulin response to meals decreasing postprandial blood glucose levels. It should only be taken with meals and meal-time doses should be skipped with any skipped meal. Approximately one month of therapy is required before a decrease in fasting blood glucose is seen. Meglitnides may have a neutral effect on weight or cause a slight increase in weight. The average weight gain caused by meglitinides appears to be lower than that caused by sulfonylureas and insulin and appears to occur only in those na?ve to oral antidiabetic agents. Due to their mechanism of action, meglitinides may cause hypoglycemia although the risk is thought to be lower than that of sulfonylureas since their action is dependent on the presence of glucose. In addition to reducing postprandial and fasting blood glucose, meglitnides have been shown to decrease glycosylated hemoglobin (HbA1c) levels, which are reflective of the last 8-10 weeks of glucose control. Meglitinides appear to be more effective at lowering postprandial blood glucose than metformin, sulfonylureas and thiazolidinediones. Nateglinide is extensively metabolized in the liver and excreted in urine (83%) and feces (10%). The major metabolites possess less activity than the parent compound. One minor metabolite, the isoprene, has the same potency as its parent compound.(In Vitro):Nateglinide inhibits typical recordings of dinitrophenol-induced KATP currents in a concentration-dependent manner. Nateglinide exhibits IC50 values of 7.4 μM and 2.4 μM for 5 mM glucose (G5) and 16 mM (G16) glucose, respectively.(In Vivo):Nateglinide (50mg/kg, orally in mice) stimulates human C-peptide secretion in the humanized mice and improved postprandial glucose concentrations.
  • 体外实验
    Nateglinide inhibits typical recordings of dinitrophenol-induced KATP currents in a concentration-dependent manner. Nateglinide exhibits IC50 values of 7.4 μM and 2.4 μM for 5 mM glucose (G5) and 16 mM (G16) glucose, respectively. RT-PCR Cell Line:Rat pancreatic β-cells.Concentration:0-100 μM.Incubation Time:~20 min.Result:Produced a complete inhibition of KATP current at concentration of 3 μM.
  • 体内实验
    Nateglinide (50mg/kg, orally in mice) stimulates human C-peptide secretion in the humanized mice and improved postprandial glucose concentrations. Animal Model:Mice.Dosage:50mg/kg.Administration:Orally at 60min before oral administration of 4 g/kg glucose.Result:Stimulates human C-peptide secretion.
  • 同义词
    A-4166 | SDZ-DJN 608
  • 通路
    Cell Cycle/DNA Damage
  • 靶点
    Potassium Channel
  • 受体
    Potassium Channel| PPARγ
  • 研究领域
    Cardiovascular Disease
  • 适应症
    ——

化学信息

  • CAS Number
    105816-04-4
  • 分子量
    317.42
  • 分子式
    C19H27NO3
  • 纯度
    >98% (HPLC)
  • 溶解度
    Ethanol: 63 mg/mL (198.47 mM); DMSO: 63 mg/mL (198.47 mM)
  • SMILES
    O=C(O)[C@@H](CC1=CC=CC=C1)NC([C@H]2CC[C@H](C(C)C)CC2)=O
  • 化学全称
    (R)-2-((1r,4R)-4-isopropylcyclohexanecarboxamido)-3-phenylpropanoic acid

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Hu S, et al. J Pharmacol Exp Ther. 2000 May;293(2):444-52.
产品手册
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