Napellonine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Napellonine 在包括细胞增殖和分子对接测定在内的初步药理学验证试验中显示出良好的抗肿瘤活性。

Napellonine shows favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays.

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Songorine is investigated itsefficacy and safety in SKOV3 tumorbearing BALB/c nude mice, songorine?inhibits EOC cell survival, invasion and migration, promoted EOC cell apoptosis and suppressed mammalian EOC tumorigenic behavior. In addition, western blot and IHC results show that songorine consistently downregulates the expression of Ncadherin, vimentin, matrix metalloproteinase (MMP)2, MMP9, phosphorylated GSK3β, βcatenin and Bcl2, and upregulated the expression of Ecadherin, cleaved caspase3, cleaved caspase9 and Bax.Songorine shows an Antiarrhythmic activity in aconitine-induced arrhythmia model in rats, exhibits LD50 and ED50 values of 142 mg and 7.3mg, respectively.

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Apoptosis

p53

Others

Others-Field

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509-24-0

357.49

C22H31NO3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (279.73 mM)

CCN1CC2(CCC(C34C2CC(C31)C56C4CC(=O)C(C5)C(=C)C6O)O)C

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(-20℃)

With Ice Pack

≥ 2 years