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NS13001
CAS No. 1063331-94-1
NS13001 ( N-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-9-methylpurin-6-amine; N-(4-Chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine )
产品货号. M23269 CAS No. 1063331-94-1
NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1126 | 有现货 |
|
| 10MG | ￥1968 | 有现货 |
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| 25MG | ￥3216 | 有现货 |
|
| 50MG | ￥4763 | 有现货 |
|
| 100MG | ￥6901 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称NS13001
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels).
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产品描述NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels). The EC50s are 1.8 and 0.14 μM for SK2 and SK3, respectively. NS13001 holds promise as a potential therapeutic agent for treatment of spinocerebellar ataxia type 2 (SCA2) and possibly other cerebellar ataxias.
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同义词N-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-9-methylpurin-6-amine; N-(4-Chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine
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通路Others
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靶点Other Targets
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受体SK2;SK3
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研究领域——
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适应症——
化学信息
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CAS Number1063331-94-1
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分子量353.8
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分子式C17H16ClN7
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纯度>98% (HPLC)
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溶解度DMSO: 90 mg/mL (254.37 mM; Need ultrasonic)
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SMILESCc1cc(C)nn1-c(nc1Nc(cc2)ccc2Cl)nc2c1ncn2C
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Kasumu AW, et al. Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2. Chem Biol. 2012 Oct 26;19(10):1340-53.
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