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NS-3623
CAS No. 343630-41-1
NS-3623 ( NS 3623;NS3623 )
产品货号. M14170 CAS No. 343630-41-1
A novel human RBC Cl-conductance blocker (IC50=210 nM) and HERG channel activitor (EC50=79.4 uM, HERG1 channel activation).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥648 | 有现货 |
|
| 10MG | ￥1037 | 有现货 |
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| 25MG | ￥2130 | 有现货 |
|
| 50MG | ￥3467 | 有现货 |
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| 100MG | ￥5176 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称NS-3623
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A novel human RBC Cl-conductance blocker (IC50=210 nM) and HERG channel activitor (EC50=79.4 uM, HERG1 channel activation).
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产品描述A novel human RBC Cl-conductance blocker (IC50=210 nM) and HERG channel activitor (EC50=79.4 uM, HERG1 channel activation); inhibits RBC g(Cl) after oral administration to normal mice (ED50= 25 mg/kg), ameliorates erythrocyte dehydration in transgenic SAD mice; increases the macroscopic current conducted by the hERG channels by increasing the time constant for channel inactivation; affects native I(Kr), decreases QT variability and distinctly decreases the occurrence of extrasystoles in the acutely bradypaced hearts.Anemia Discontinued
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同义词NS 3623;NS3623
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通路Cell Cycle/DNA Damage
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靶点Potassium Channel
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受体Potassium Channel
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研究领域Other Indications
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适应症Anemia
化学信息
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CAS Number343630-41-1
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分子量427.19
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分子式C15H10BrF3N6O
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(NC1=CC=CC(C(F)(F)F)=C1)NC2=CC=C(Br)C=C2C3=NNN=N3
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化学全称N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Bennekou P, et al. Blood. 2001 Mar 1;97(5):1451-7.
2. Hansen RS, et al. Mol Pharmacol. 2006 Oct;70(4):1319-29.
3. Hansen RS, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):996-1002.
4. Hansen RS, et al. J Cardiovasc Pharmacol. 2008 Jul;52(1):35-41.
2. Hansen RS, et al. Mol Pharmacol. 2006 Oct;70(4):1319-29.
3. Hansen RS, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):996-1002.
4. Hansen RS, et al. J Cardiovasc Pharmacol. 2008 Jul;52(1):35-41.
产品手册
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