NPT200-11 ( —— )

产品货号. M28510 CAS No. 2227057-23-8

COA

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产品名称

NPT200-11
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

NPT200-11 是一种口服生物可利用的脑穿透抑制剂，可抑制 α-突触核蛋白 (ASYN) 错误折叠和聚集的积累。
产品描述

NPT200-11 is an orally bioavailable and brain penetrating inhibitor of accumulation of alpha-synuclein (ASYN) misfolding and aggregation. NPT200-11 can be used in studies about the underlying pathology of synucleinopathies including Parkinson's disease (PD), dementia with Lewy bodies (DLB) and Multiple Systems Atrophy (MSA).(In Vivo):In the Line 61 transgenic mouse model overexpressing human wild type ASYN, NPT200-11 (5 mg/kg; i.p.) results in a time-dependent and progressive reduction in retinal ASYN pathology. NPT200-11 reduced alpha-synuclein pathology in cortex, reduced associated neuroinflammation (astrogliosis), normalized striatal levels of the dopamine transporter (DAT) and improved motor function.
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