NPD13668 ( NPD-13668 | NPD 13668 )

产品货号. M16274 CAS No. 864819-54-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

NPD13668
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

NPD13668 (NPD-13668) 是一种 EZH2 介导的基因沉默的化学新型调节剂，抑制 EZH2/PCR2 活性并降低 H3K27me3 水平。
产品描述

NPD13668 (NPD-13668) is a chemical novel modulator of EZH2-mediated gene silencing, inhibits EZH2/PCR2 activity and decreases H3K27me3 levels; reactivates the expression of silenced H3K27me3 target genes together with depletion of the H3K27me3 modification; effectively suppressed the cell growth of solid tumors even without EZH2 active mutations; inhibits cell proliferation in many cancer cells (PC3 cell IC50=5.39 uM); NPD13668 is a potential modulator of EZH2 methyltransferase activity.
体外实验

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体内实验

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同义词

NPD-13668 | NPD 13668
通路

Chromatin/Epigenetic
靶点

HMTase
受体

HMTase
研究领域

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适应症

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CAS Number

864819-54-5
分子量

392.411
分子式

C22H20N2O5
纯度

>98% (HPLC)
溶解度

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SMILES

CC1=C(C(=O)OC2=C1C=CC(=C2O)O)CC(=O)NCCC3=CNC4=CC=CC=C43
化学全称

N-(2-(1H-indol-3-yl)ethyl)-2-(7,8-dihydroxy-4-methyl-2-oxo-2H-chromen-3-yl)acetamide