NMS-P937

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

NMS-P937 (NMS1286937) 是一种口服特异性 Polo 样激酶 1 (PLK1) 抑制剂，IC50 为 2 nM。 NMS-P937 对 PLK1 的特异性比 PLK2/PLK3 高 5000 倍。

Onvansertib, also know as NMS-P937, PCM-075 and NMS1286937, is a n orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor NMS-1286937 selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell-cycle arrest at the G1 and G2 stages without apoptosis in normal cells. PLK1 inhibition may result in the inhibition of proliferation in PLK1-overexpressing tumor cells. PLK1 is a serine/threonine protein kinase crucial in the regulation of mitosis.

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PCM-075 | PCM 075 | NMS1286937

Others

Other Targets

PLK1| PLK2| PLK3

Cancer

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1034616-18-6

532.52

C24H27F3N8O3

>98% (HPLC)

DMSO : 21 mg/mL. 39.44 mM;

CN1CCN(CC1)c1cc(c(cc1)OC(F)(F)F)Nc1ncc2CCc3c(c2n1)n(nc3C(=O)N)CCO

1-(2-hydroxyethyl)-8-((5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

(-20℃)

With Ice Pack

≥ 2 years