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NMS-859
CAS No. 1449236-96-7
NMS-859 ( ZINC169324353 )
产品货号. M26335 CAS No. 1449236-96-7
NMS-859 is an effective and covalent inhibitor of valosin-containing protein (VCP)/p97 with IC50s of 0.37 μM and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1839 | 有现货 |
|
| 5MG | ￥2811 | 有现货 |
|
| 10MG | ￥4026 | 有现货 |
|
| 25MG | ￥6423 | 有现货 |
|
| 50MG | ￥9153 | 有现货 |
|
| 100MG | ￥12312 | 有现货 |
|
| 500MG | ￥24057 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称NMS-859
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述NMS-859 is an effective and covalent inhibitor of valosin-containing protein (VCP)/p97 with IC50s of 0.37 μM and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.
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产品描述NMS-859 is an effective and covalent inhibitor of valosin-containing protein (VCP)/p97 with IC50s of 0.37 μM and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.(In Vitro):NMS-859 suppresses the cell proliferation with IC50s of 3.0 μM and 3.5 μM in HeLa and HCT116 cell lines, respectively. NMS-859 shows weak inhibitory activity against VCPC522T.
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同义词ZINC169324353
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通路Others
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靶点Other Targets
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受体ADC Cytotoxin; Microtubule/Tubulin
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研究领域——
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适应症——
化学信息
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CAS Number1449236-96-7
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分子量349.8
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分子式C15H12ClN3O3S
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纯度>98% (HPLC)
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溶解度——
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SMILESClCC(=O)Nc1cccc(NC2=NS(=O)(=O)c3ccccc23)c1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Francisco JA, et al. cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity. Blood. 2003 Aug 15;102(4):1458-65.
产品手册
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