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NMS-859

CAS No. 1449236-96-7

NMS-859 ( ZINC169324353 )

产品货号. M26335 CAS No. 1449236-96-7

NMS-859 is an effective and covalent inhibitor of valosin-containing protein (VCP)/p97 with IC50s of 0.37 μM and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥1839 有现货
5MG ¥2811 有现货
10MG ¥4026 有现货
25MG ¥6423 有现货
50MG ¥9153 有现货
100MG ¥12312 有现货
500MG ¥24057 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    NMS-859
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    NMS-859 is an effective and covalent inhibitor of valosin-containing protein (VCP)/p97 with IC50s of 0.37 μM and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.
  • 产品描述
    NMS-859 is an effective and covalent inhibitor of valosin-containing protein (VCP)/p97 with IC50s of 0.37 μM and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.(In Vitro):NMS-859 suppresses the cell proliferation with IC50s of 3.0 μM and 3.5 μM in HeLa and HCT116 cell lines, respectively. NMS-859 shows weak inhibitory activity against VCPC522T.
  • 同义词
    ZINC169324353
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    ADC Cytotoxin; Microtubule/Tubulin
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    1449236-96-7
  • 分子量
    349.8
  • 分子式
    C15H12ClN3O3S
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    ClCC(=O)Nc1cccc(NC2=NS(=O)(=O)c3ccccc23)c1
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Francisco JA, et al. cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity. Blood. 2003 Aug 15;102(4):1458-65.
产品手册
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