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NLRP3-IN-9
CAS No. 88039-46-7
NLRP3-IN-9 ( NLRP3 IN 9 | NLRP3IN9 | INF-4E | INF 4E | INF4E )
产品货号. M27905 CAS No. 88039-46-7
NLRP3-IN-9 是 NLRP3 ATPase 和 caspase-1 的抑制剂。 NLRP3-IN-9 通过不可逆地捕获硫醇亲核试剂发挥作用，以时间和浓度依赖性方式防止 ATP 和尼日利亚霉素触发的人 THP-1 细胞焦亡。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥794 | 有现货 |
|
| 10MG | ￥1442 | 有现货 |
|
| 25MG | ￥3216 | 有现货 |
|
| 50MG | ￥4771 | 有现货 |
|
| 100MG | ￥6828 | 有现货 |
|
| 500MG | ￥14013 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称NLRP3-IN-9
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述NLRP3-IN-9 是 NLRP3 ATPase 和 caspase-1 的抑制剂。 NLRP3-IN-9 通过不可逆地捕获硫醇亲核试剂发挥作用，以时间和浓度依赖性方式防止 ATP 和尼日利亚霉素触发的人 THP-1 细胞焦亡。
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产品描述NLRP3-IN-9 is an inhibitor of NLRP3 ATPase and caspase-1. NLRP3-IN-9 acts by irreversibly trapping thiol nucleophiles, which prevents both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- and concentration-dependent manner.
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体外实验INF4E (compound 9) preventes both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- and concentration-dependent manner.
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体内实验INF4E significantly reduces the in infarct size and lactate dehydrogenase release and improvement in postischemic left ventricular pressure.INF4E attenuates the formation of NLRP3 inflammasome complex was induced by myocardial IR (ischemia/reperfusion) in a time-dependent way.
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同义词NLRP3 IN 9 | NLRP3IN9 | INF-4E | INF 4E | INF4E
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通路NF-κB
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靶点NOD
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number88039-46-7
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分子量240.68
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分子式C12H13ClO3
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : ≥ 100 mg/mL (415.49 mM)
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SMILESCCOC(=O)C(=C)C(O)c1ccccc1Cl
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Cooley RB, Sondermann H. Probing Protein-Protein Interactions with Genetically Encoded Photoactivatable Cross-Linkers. Methods Mol Biol. 2017;1657:331-345.
产品手册
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