NLRP3-IN-11

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

NLRP3-IN-11 是一种 NLRP3 蛋白抑制剂。NLRP3-IN-11 具有生物活性，IC50 值 <0.3 μM。NLRP3-IN-11 可用于炎症和退行性疾病的研究，包括 NASH、动脉粥样硬化和其他心血管疾病、阿尔茨海默病、帕金森病、糖尿病、痛风和许多其他自身炎症性疾病。

NLRP3-IN-11 is a NLR family pyrin domain containing 3 (NLRP3) proteins inhibitor. NLRP3-IN-11 has biological activity for NLRP3 with an IC50 value of <0.3 μM. NLRP3-IN-11 can be used for the researh of inflammatory and degenerative diseases including NASH, atherosclerosis and other cardiovascular diseases, Alzheimer's disease, Parkinson's disease, diabetes, gout, and numerous other autoinflammatory diseases.

NLRP3-IN-11 has biological activity with an IC50 value of <0.3 μM in human PBMC NLRP3 assay.

——

——

NF-κB

NOD

NOD

——

——

2769040-91-5

344.8

C17H17ClN4O2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 125 mg/mL (362.53 mM; 超声助溶 )

N(CC(C)(C)O)C=1C2=C(C(=NN1)C3=C(O)C=C(Cl)C=C3)C=CN=C2

——

(-20℃)

With Ice Pack

≥ 2 years