NCT-503 ( NCT-503; NCT 503; NCT503 )

产品货号. M18172 CAS No. 1916571-90-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

拼团产品询价大包装询价加入购物车

产品名称

NCT-503
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells.
产品描述

NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells with an IC50 value of 2.5 μM.
同义词

NCT-503; NCT 503; NCT503
通路

Others
靶点

Other Targets
受体

PHGDH (Cell-free) ; FLT3; AXL
研究领域

——
适应症

——

CAS Number

1916571-90-8
分子量

408.49
分子式

C20H23F3N4S
纯度

98%
溶解度

DMSO : 50 mg/mL 122.41 mM;
SMILES

Cc1cc(nc(c1)NC(=S)N1CCN(CC1)Cc1ccc(cc1)C(F)(F)F)C
化学全称

N-(4,6-dimethylpyridin-2-yl)-4-(4-(trifluoromethyl)benzyl)piperazine-1-carbothioamide

1. Pacold ME, et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat Chem Biol. 2016 Jun;12(6):452-8.

计算器

产品手册

关联产品

Methyl nomilinate

Methyl nomilinate from citrus can modulate cell cycle regulators to induce cytotoxicity in human colon cancer (SW480) cells in vitro.
Bak BH3

This peptide, generated from the BH3 domain of Bak (Flu-BakBH3), has been shown to have high-affinity binding to a surface pocket of the Bcl-XL protein that is required for its death antagonist function.
Deferoxamine mesylat...

An iron chelator that binds iron and aluminium; increases HIF-1α transactivation in diabetes by preventing iron-catalyzed reactive oxygen stress.