NCGC00092410

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

NCGC00092410 是一种有效，选择性和非糖性葡萄糖脑苷脂酶 (glucocerebrosidase, GC) 抑制剂，IC50 值为 31 nM。NCGC00092410 对相关水解酶没有活性。NCGC00092410 是一种 GC 分子伴侣，可提高突变型细胞株中葡萄糖脑苷脂酶的活性和溶酶体定位。NCGC00092410可用于戈谢病的研究。

NCGC00092410 is a potent, selective, and nonsugar glucocerebrosidase (GC) inhibitor, with an IC50 of 31 nM. NCGC00092410 shows no activity against the related hydrolases at concentrations up to 77 μM. NCGC00092410, a GC chaperone, and increases the activity and lysosomal localization of glucocerebrosidase in mutant cell lines. NCGC00092410 can be used for the research of Gaucher disease.

NCGC00092410 (7.3-130 nM; 25 min) inhibits the GC activity at various substrate concentrations (10-150 μM) in a dose-dependent manner.NCGC00092410 (55-40 μM; 2 d) increases the GC activity in the N370S mutant fibroblasts.NCGC00092410 (40 μM; 60-72 h) increases the lysosomal localization of GC in gaucher fibroblasts.

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Others

Other Targets

Glucosidase

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442898-34-2

353.46

C21H27N3O2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 41.67 mg/mL (117.89 mM; 超声助溶 )

Cc1cc(nc2ccc(NC(=O)C3CCCCC3)cc12)N1CCOCC1

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(-20℃)

With Ice Pack

≥ 2 years