NAcM-OPT

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

NAcM-OPT 是一种特异性、可逆的小分子抑制剂，靶向 N-乙酰基-UBE2M 与 DCN1 的相互作用，在 TR-FRET 测定中 IC50 为 79 nM。

NAcM-OPT is a specific, reversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 79 nM in TR-FRET assays; also inhibits DCN2, but has no activity against DCN3, DCN4, or DCN5; inhibits NEDD8 ligation in vitro and in cells, and suppress anchorage-independent growth of a cell line with DCN1 amplification.

NAcM-OPT (Compound 67) is orally bioavailable, well tolerated in mice, and currently used to study the effects of acute pharmacologic inhibition of the DCN1-UBE2M interaction on the NEDD8/CUL pathway.

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NAcM-OPT | NAcM OPT | NAcMOPT

Proteasome/Ubiquitin

E2

DCN1-UBE2M

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2089293-61-6

434.405

C23H29Cl2N3O

>98% (HPLC)

DMSO: 100 mg/mL, 230.20 mM; Water: Insoluble （ < 1 mg/ml refers to the product slightly soluble or insoluble )

O=C(NC1=CC=C(Cl)C(Cl)=C1)N(CC2=CC=CC=C2)C3CCN(CCCC)CC3

1-benzyl-1-(1-butylpiperidin-4-yl)-3-(3,4-dichlorophenyl)urea

(-20℃)

With Ice Pack

≥ 2 years