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NAV-2729

CAS No. 419547-11-8

NAV-2729 ( —— )

产品货号. M28469 CAS No. 419547-11-8

NAV-2729 抑制六种 ArfGEF(人 ARNO、EFA6、BIG1 和 BRAG2 以及军团菌和立克次体 RalF),其中针对 BRAG2、Arf1 和 Arf6 的作用最强。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥308 有现货
5MG ¥494 有现货
10MG ¥786 有现货
25MG ¥1742 有现货
50MG ¥2576 有现货
100MG ¥3864 有现货
500MG ¥7995 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    NAV-2729
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    NAV-2729 抑制六种 ArfGEF(人 ARNO、EFA6、BIG1 和 BRAG2 以及军团菌和立克次体 RalF),其中针对 BRAG2、Arf1 和 Arf6 的作用最强。
  • 产品描述
    NAV-2729 inhibits six ArfGEFs (human ARNO, EFA6, BIG1, and BRAG2 and Legionella and Rickettsia RalF), the strongest effects being against BRAG2, Arf1 and Arf6.(In Vitro):NAV-2729(25 μM) inhibits spontaneous nucleotide exchange of Δ13Arf6 by ~15%. NAV-2729 inhibits the activation of Δ13Arf6 by BRAG2Sec7PH by 25%. Δ17Arf1 has no measurable spontaneous nucleotide exchange. Activation of Δ17Arf1 by BRAG2Sec7PH is inhibited by NAV-2729, and the efficiency is markedly higher than that for Arf6 (50%). In a dose-response experiment, nucleotide exchange rates are reduced by 50% by 10 μM NAV-2729 for Δ17Arf1 while 50% inhibition is not achieved even at 25 μM NAV-2729 for Δ13Arf6. NAV-2729 blocks ARNO- and GEP100-mediated guanine nucleotide exchange on Arf6 and spontaneous activation of Arf6 and its activation by cytohesins and BRAG. The treatment of uveal melanoma cells with NAV-2729 interferes with anchorage-independent growth of the cell. NAV-2729 is more effective toward Arf1 than Arf6. (In Vivo):In orthotopic xenograft mouse model of uveal melanoma, systemic treatment of NAV-2729 interfere with tumorigenesis and tumor growth.
  • 体外实验
    ——
  • 体内实验
    ——
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    CDK7
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    419547-11-8
  • 分子量
    456.89
  • 分子式
    C25H17ClN4O3
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO : 50 mg/mL (109.44 mM)
  • SMILES
    [O-][N+](=O)c1ccc(cc1)-c1cc(=O)n2nc(Cc3ccccc3)c(-c3ccc(Cl)cc3)c2[nH]1
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

产品手册
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