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N106
CAS No. 862974-25-2
N106 ( N-106; N 106 )
产品货号. M27902 CAS No. 862974-25-2
N106 directly activates the SUMO-activating enzyme, E1 ligase, and triggers intrinsic SUMOylation of SERCA2a.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥786 | 有现货 |
|
| 10MG | ￥1442 | 有现货 |
|
| 25MG | ￥3216 | 有现货 |
|
| 50MG | ￥4771 | 有现货 |
|
| 100MG | ￥6828 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称N106
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述N106 directly activates the SUMO-activating enzyme, E1 ligase, and triggers intrinsic SUMOylation of SERCA2a.
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产品描述N106 directly activates the SUMO-activating enzyme, E1 ligase, and triggers intrinsic SUMOylation of SERCA2a.(In Vitro):N106 (10?min) increases cell contractility, calcium-transient SERCA2a's ATPase activity and SUMOylation. These effects are sustained at 24?h in cardiomyocytes.(In Vivo):N106 (10 mg/kg) significantly improves ventricular function in mice with heart failure. N106(10?mg/kg; i.v.) exhibits a half-life of 65.4?min and a Cmax of ～2.24?μM.
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同义词N-106; N 106
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通路Others
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靶点Other Targets
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受体HD1-A;HD1-B;HD2;HDAC1;HDAC2;HDAC3;HDAC4;HDAC5;HDAC6;HDAC7;HDAC8;HDAC9;HDAC10;HDAC11
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研究领域——
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适应症——
化学信息
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CAS Number862974-25-2
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分子量354.4
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分子式C17H14N4O3S
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纯度>98% (HPLC)
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溶解度——
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SMILESCOc1ccc(cc1)-c1nnc(Nc2nc3c(OC)cccc3s2)o1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Zappasodi R, et al. Pleiotropic antitumor effects of the pan-HDAC inhibitor ITF2357 against c-Myc-overexpressing human B-cell non-Hodgkin lymphomas. Int J Cancer. 2014 Nov 1;135(9):2034-45.
产品手册
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