CRT0044876 is a potent and selective APE1 inhibitor with IC50 of ~3 μM.

Acesulfame potassium is a non-nutritive sweetener.

3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α±- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like receptor 4 expression-mediated activation of the Akt, ERK and NF-κB pathways, it may exert an inhibitory effect against the pro-inflammatory mediator-induced skin disease.