Monocrotaline

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Monocrotaline 是一种 11 元大环吡咯利西啶生物碱。Monocrotaline 对 OCT-1 和 OCT-2 有抑制作用，其 IC50 值分别为 36.8 μM 和 1.8 mM。Monocrotaline 具有抗肿瘤活性，对肝癌细胞有一定的细胞毒性。Monocrotaline 用于在啮齿动物中诱导肺动脉高压模型。

Extracted from Legume Crotalaria assamica;Suitability:Methanol,ethanol,chloroform;Store the product in sealed,cool and dry condition.(In Vitro):Monocrotaline (MCT) is an 11-membered macrocyclic pyrrolizidine alkaloid (PA) derived from the seeds of the Crotalaria pallida plant. Monocrotaline a natural ligand exhibits dose-dependent cytotoxicity with potent antineoplastic activity. The in vitro cytotoxicity of monocrotaline is proved at IC50 24.966 μg/mL and genotoxicity at 2 X IC50 against HepG2 cells. (In Vivo):MCT causes a pulmonary vascular syndrome in rats characterized by proliferative pulmonary vasculitis, pulmonary hypertension (PH), and cor pulmonale. Among preclinical models of pulmonary arterial hypertension (PAH), monocrotaline animal model offers the advantage of mimic several key aspects of human PAH, including vascular remodeling, proliferation of smooth muscle cells, endothelial dysfunction, upregulation of inflammatory cytokines, and right ventricle failure, requiring a single drug injection. Changes in multiple pathways associated with the development of PH, including activated glycolysis, increased markers of proliferation, disruptions in carnitine homeostasis, increased inflammatory and fibrosis biomarkers, and a reduction in glutathione biosynthesis are observed with the injection of monocrotaline.

Cell Viability Assay Cell Line:HepG2 cells Concentration:25, 50, 100 and 200 μg/mL Incubation Time:48 h Result:Induced apoptosis rate was dose-dependent.

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Crotaline | MCT | NSC 28693

TGF-beta/Smad

TGFBR

TGFβ

Metabolic Disease

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315-22-0

325.36

C16H23NO6

>98% (HPLC)

DMSO: 10 mM

O=C(O[C@]1([H])CCN2[C@]1([H])C(CO3)=CC2)[C@H](C)[C@@](C)(O)[C@@](C)(O)C3=O

20-Norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, (13-alpha,14-alpha)- (9CI)

(-20℃)

With Ice Pack

≥ 2 years