Mivebresib ( ABBV-075;ABBV075 )

产品货号. M11890 CAS No. 1445993-26-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Mivebresib
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Mivebresib (ABBV-075) is a potent and orally available BET bromodomain inhibitor with Ki of 1.0, 12.2, 1.5, and 2.2 nM for BRD2, BRD3, BRD4 and BRDT, respectively.
产品描述

Mivebresib (ABBV-075) is a potent and orally available BET bromodomain inhibitor with Ki of 1.0, 12.2, 1.5, and 2.2 nM for BRD2, BRD3, BRD4 and BRDT, respectively; displays 54-fold selectivity over EP300, has potential weak activity against SMARCA4 (70% inhibition at 1 uM), Kd >1 uM for 18 other bromodomains; exhibits inhibition of c-Myc expression and displacing BRD4 from the Myc promoter; dose-dependently inhibits IL-6 concentration in a murine model of LPS-induced endotoxic shock, shows vivo antitumor efficacy in a Kasumi-1 AML mouse xenograft model.Breast Cancer Phase 1 Clinical
同义词

ABBV-075;ABBV075
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

BET
研究领域

Cancer
适应症

Breast Cancer

CAS Number

1445993-26-9
分子量

459.47
分子式

C22H19F2N3O4S
纯度

>98% (HPLC)
溶解度

DMSO: ≥ 37 mg/mL
SMILES

CCS(=O)(NC1=CC=C(OC2=CC=C(F)C=C2F)C(C3=CN(C)C(C4=C3C=CN4)=O)=C1)=O
化学全称

Ethanesulfonamide, N-[4-(2,4-difluorophenoxy)-3-(6,7-dihydro-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]-

1. McDaniel KF, et al. J Med Chem. 2017 Oct 26;60(20):8369-8384.

计算器

产品手册

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