Mitonafide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Mitonafide 抑制结核分枝杆菌 NAD+ 依赖性 DNA 连接酶 A 的活性。Mitonafide 是一种 DNA 嵌入剂。

Mitonafide suppresses the activity of M. tuberculosis NAD+ dependent DNA ligase A. Mitonafide is a DNA intercalating agent.

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Mitonafide (0.5 and 1 mg/kg, i.p., 1-7 days) shows antitumoral potency in S-180 bearing mice.Mitonafide (5 mg/kg, i.p., twice a day) shows anticancer activity in HepG2 xenograft model.Mitonafide (single i.p. injection, S-180 bearing mice) shows the LD50 value of 10.0 mg/kg. Animal Model:S-180 bearing mice Dosage:0.5 mg/kg and 1 mg/kg Administration:Intraperitoneal injection (i.p.) for 1-7 days Result:Increased in median survival times.Animal Model:HepG2 xenograft model Dosage:5 mg/kg Administration:Intraperitoneal injection (i.p.), twice a day.Result:Exhibited a relative tumor increment rates (T/C) value of 28.8%.

NSC300288 | NSC-300288 | NSC 300288 | Mitonafide

GPCR/G Protein

Antibacterial

ATP citrate lyase|GPR40|GPR120

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54824-17-8

313.313

C16H15N3O4

>98% (HPLC)

In Vitro:?DMSO : 62.5 mg/mL (199.48 mM)

CN(C)CCN1C(=O)c2cccc3cc(cc(C1=O)c23)[N+]([O-])=O

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(-20℃)

With Ice Pack

≥ 2 years