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Mito-TEMPO

CAS No. 1334850-99-5

Mito-TEMPO ( —— )

产品货号. M23487 CAS No. 1334850-99-5

Mito-TEMPO 是一种靶向线粒体的超氧化物歧化酶模拟物。 Mito-TEMPO 具有超氧化物和烷基自由基清除特性。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥413 有现货
10MG ¥721 有现货
25MG ¥1442 有现货
50MG ¥2778 有现货
100MG ¥4625 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Mito-TEMPO
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Mito-TEMPO 是一种靶向线粒体的超氧化物歧化酶模拟物。 Mito-TEMPO 具有超氧化物和烷基自由基清除特性。
  • 产品描述
    Mito-TEMPO is a mitochondria-targeted superoxide dismutase mimetic. Mito-TEMPO with superoxide and alkyl radical scavenging properties.(In Vivo):Mito-TEMPO (MT) greatly attenuates the increase in ALT activities and reduces the areas of necrosis at both time points, indicating that the protection by Mito-TEMPO is sustained until at least 24 h post-APAP. Mito-Tempo could induce secondary apoptosis in the late phase of APAP hepatotoxicity. Mito-Tempo induces secondary apoptosis after APAP overdose by inhibition of RIP3.
  • 体外实验
    ——
  • 体内实验
    Mito-TEMPO (MT) greatly attenuates the increase in ALT activities and reduces the areas of necrosis at both time points, indicating that the protection by Mito-TEMPO is sustained until at least 24 h post-APAP. Mito-Tempo could induce secondary apoptosis in the late phase of APAP hepatotoxicity. Mito-Tempo induces secondary apoptosis after APAP overdose by inhibition of RIP3.
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Mitochondrial Metabolism
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    1334850-99-5
  • 分子量
    510.03
  • 分子式
    C29H35ClN2O2P
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO:125 mg/mL (245.08 mM; Need ultrasonic);H2O:60 mg/mL (117.64 mM; Need ultrasonic)
  • SMILES
    [O]N1C(C)(C)CC(NC(C[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)=O)CC1(C)C.[Cl-]
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Du K, et al. Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity. Arch Toxicol. 2018 Oct 15.
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