Miclxin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Miclxin (DS37262926) 是突变体 β-catenin 的有效抑制剂，参与 Wnt 信号通路。Miclxin 可诱导 β-catenin 依赖性凋亡，导致线粒体损伤，线粒体膜丢失。Miclxin 通过靶向 MIC60 杀伤肿瘤，MIC60 是线粒体接触位点和嵴组织系统 (MICOS) 复合体的主要组成部分。

Miclxin (DS37262926) is a potent inhibitor of mutant β-catenin, involving in Wnt signaling pathway. Miclxin induces β-catenin-dependent apoptosis, leads to severe mitochondrial damage with the loss of mitochondrial membrane. Miclxin kills tumor via targeting to MIC60, a major components of the mitochondrial contact site and cristae organizing system (MICOS) complex.

Cell Viability Assay Cell Line:HCT116 (CTNNB1 +/–) and (CTNNB1 △45/–)Concentration:0, 5, 8, 10, 12, and 15 μM Incubation Time:48 hours Result:Inhibited cell growth with inhibition rate of 100% at 15 μM.

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Wnt/Notch/Hedgehog

Wnt/beta/catenin

Wnt/beta-catenin

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2494198-61-5

441.52

C26H27N5O2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 10 mg/mL (22.65 mM; 超声助溶 (<80°C)

N(CC1=CC(OC)=CC=C1)C=2C3=C(N=C(N2)N4CC(CC4)C=5C=CC=NC5)C=C(OC)C=C3

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(-20℃)

With Ice Pack

≥ 2 years