Metronidazole

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甲硝唑是一种硝基咪唑抗生素化合物，特别用于厌氧菌和原生动物。

Metronidazole is a nitroimidazole antibiotic medication used particularly for anaerobic bacteria and protozoa.(In Vitro):Metronidazole displays inhibitory activity towards anaerobic protozoa Trichomonas vaginalis, Entamoeba histolytica, Giardia lamblia, and Balantidium coli.Metronidazole (4-8 μg/mL) inhibits anaerobic bacteria and shows good bactericidal activity.Metronidazole (0.1 μg/mL-0.01 mg/mL; 12-96 h) induces granular formation and triggers apoptosis in Blastocystis sp.(In Vivo):Metronidazole (135 mg/kg/d; p.o.; 28 d) can cross the blood brain barrier, and exhibits neurotoxicity under long term administration in rats.Metronidazole (1 g/L; p.o.; 4 weeks) results skeletal muscle atrophy and changes the expression of genes involved in the muscle peripheral circadian rhythm machinery and metabolic regulation.

Metronidazole displays inhibitory activity towards anaerobic protozoa Trichomonas vaginalis, Entamoeba histolytica, Giardia lamblia, and Balantidium coli.Metronidazole (4-8 μg/mL) inhibits anaerobic bacteria and shows good bactericidal activity.Metronidazole (0.1 μg/mL-0.01 mg/mL; 12-96 h) induces granular formation and triggers apoptosis in Blastocystis sp. Apoptosis Analysis Cell Line:Blastocystis sp. Cells Concentration:0.1 μg/mL-0.01 mg/mL Incubation Time:12, 24, 48, 60, 72, 84, 96 hours Result:Decreased cell diameter, as a hallmark of an apoptotic cell, and resulted cell shrinkage.

Metronidazole (135 mg/kg/d; p.o.; 28 d) can cross the blood brain barrier, and exhibits neurotoxicity under long term administration in rats.Metronidazole (1 g/L; p.o.; 4 weeks) results skeletal muscle atrophy and changes the expression of genes involved in the muscle peripheral circadian rhythm machinery and metabolic regulation. Animal Model:Sprague-Dawley (SD) rats (200-220 g) Dosage:135 mg/kg Administration:Oral gavage; once daily; 28 days Result:Caused inflammatory markers increasing, including iNOS, eNOS, Bax and caspase 3 protein expressions increasing and caused oxidative stress damage in brain tissue, with MDA content rising.Animal Model:SPF C57Bl/6J mice (6-7 months old) Dosage:1 g/L Administration:Oral gavage; provided with drinking water for 4 weeks, changed twice weekly Result:Resulted the muscle core clock and effector genes Cry2, Ror-β, E4BP4, PP ARγ and adiponectin expression increasing. Decreased hind limb muscle weight and resulted in smaller fibers in the tibialis anterior muscle.

MNZ | NSC 50364 | NSC 69587

Microbiology/Virology

Antifection

14-α Demethylase| Fe hydrogenase 1| NADPH nitroreductase

Infection

——

443-48-1

171.16

C6H9N3O3

>98% (HPLC)

DMSO: 34 mg/mL (198.65 mM)

O=[N+](C1=CN=C(C)N1CCO)[O-]

2-(2-methyl-5-nitroimidazol-1-yl)ethanol

(-20℃)

With Ice Pack

≥ 2 years