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Memantine
CAS No. 19982-08-2
Memantine ( —— )
产品货号. M27356 CAS No. 19982-08-2
美金刚是一种金刚烷胺衍生物,具有一定的多巴胺能作用,已被提议作为抗帕金森病化合物,可用于治疗中度至重度阿尔茨海默病。它通过阻断 NMDA 受体作用于谷氨酸能系统。
纯度: >98% (HPLC)
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规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥405 | 有现货 |
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10MG | ¥567 | 有现货 |
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25MG | ¥923 | 有现货 |
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50MG | ¥1353 | 有现货 |
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100MG | ¥2009 | 有现货 |
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500MG | ¥4334 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Memantine
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述美金刚是一种金刚烷胺衍生物,具有一定的多巴胺能作用,已被提议作为抗帕金森病化合物,可用于治疗中度至重度阿尔茨海默病。它通过阻断 NMDA 受体作用于谷氨酸能系统。
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产品描述Memantine, an amantadine derivative with some dopaminergic effects, has been proposed as an antiparkinson agent and has may be used to treat moderate to severe Alzheimer's disease. It acts on the glutamatergic system by blocking NMDA receptors.
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体外实验——
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体内实验Memantine (1, 5 and 10, 15 mg/kg; i.p.; daily for 15-20 days) significantly decreased the large LTP recorded in hippocampal slices from aged animals.Memantine (1-3 mg/kg; per os (p.o.)) for 14 days significantly improves depressive-like behaviors in olfactory bulbectomized (OBX) mice, as assessed using the tail-suspension and forced-swim tests. Animal Model:Male Wistar rats Dosage:1, 5 and 10, 15 mg/kg Administration:i.p.; daily for 15-20 days Result:Significantly decreased the large LTP recorded in hippocampal slices from aged animals.
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同义词——
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通路Others
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靶点Other Targets
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受体Endogenous Metabolite
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研究领域——
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适应症——
化学信息
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CAS Number19982-08-2
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分子量179.307
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分子式C12H21N
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纯度>98% (HPLC)
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溶解度——
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SMILESC[C@@]12CC3C[C@@](C)(C1)CC(N)(C3)C2
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.SUZUKI T, SUGII M, KAKIMOTO T. Metabolic incorporation of L-valine-[14C] into S-(2-carboxypropyl) glutathione and S-(2-carboxypropyl) cysteine in garlic. Chem Pharm Bull (Tokyo). 1962 Apr;10:328-31.
产品手册
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