
Mefloquine
CAS No. 53230-10-7
Mefloquine ( Lariam | Ro 215998 | Ro-215998 | Ro215998 | WR 142490 )
产品货号. M26006 CAS No. 53230-10-7
甲氟喹是一种喹啉抗疟药,是一种抗 SARS-CoV-2 进入抑制剂。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥2722 | 有现货 |
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10MG | ¥4026 | 有现货 |
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25MG | ¥6423 | 有现货 |
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50MG | ¥9153 | 有现货 |
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100MG | ¥12312 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Mefloquine
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述甲氟喹是一种喹啉抗疟药,是一种抗 SARS-CoV-2 进入抑制剂。
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产品描述Mefloquine, a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. Mefloquine can be used for malaria, systemic lupus erythematosus, and cancer research.
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体外实验Mefloquine selectively inhibits prostate cancer (PCa) cell growth with an IC50 of ~10 μM. Mefloquine also induces hyperpolarization of the mitochondrial membrane potential (MMP), as well as ROS generation.Mefloquine (10 μM)-mediated ROS simultaneously downregulated Akt phosphorylation and activated ERK, JNK and AMPK signaling in PC3 cells.Mefloquine shows higher anti-SARS-CoV-2 activity than Hydroxychloroquine in VeroE6/TMPRSS2 and Calu-3 cells, with IC50 of 1.28 μM, IC90 of 2.31 μM, and IC99 of 4.39 μM in VeroE6/TMPRSS2 cells. Mefloquine inhibits viral entry after viral attachment to the target cell.
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体内实验Mefloquine (5 mg/kg; i.p.; daily; 14 days) reverses the lower vertebral cancellous bone volume and bone formation; and has modest effects on cortical bone volume, thickness, and moment of inertia in old mice.
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同义词Lariam | Ro 215998 | Ro-215998 | Ro215998 | WR 142490
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通路Others
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靶点Other Targets
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受体Bacterial
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研究领域——
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适应症——
化学信息
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CAS Number53230-10-7
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分子量378.318
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分子式C17H16F6N2O
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纯度>98% (HPLC)
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溶解度——
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SMILESO[C@H]([C@H]1CCCCN1)c1cc(nc2c(cccc12)C(F)(F)F)C(F)(F)F
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Isolation, identification and antimicrobial activity of ombuoside from Stevia triflora.Ann Pharm Fr. 1997;55(6):262-8.
产品手册




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