
Malotilate
CAS No. 59937-28-9
Malotilate ( Malotilate | CL-1500 | NKK 105 | NKK-105 )
产品货号. M15231 CAS No. 59937-28-9
Malotilate (NKK 105) 是一种口服活性的促肝药,是一种抗纤维化物质,可选择性抑制 5-lipoxygenase (5-LOX) (IC50=4.7 μM)。 Malotilate 通过降低肝脏乙醛水平并防止转铁蛋白保留在肝细胞中,从而预防了酒精-吡唑肝炎中肝细胞损伤的发展。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥365 | 有现货 |
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10MG | ¥583 | 有现货 |
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25MG | ¥737 | 有现货 |
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50MG | ¥988 | 有现货 |
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100MG | ¥1604 | 有现货 |
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200MG | ¥2090 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Malotilate
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Malotilate (NKK 105) 是一种口服活性的促肝药,是一种抗纤维化物质,可选择性抑制 5-lipoxygenase (5-LOX) (IC50=4.7 μM)。 Malotilate 通过降低肝脏乙醛水平并防止转铁蛋白保留在肝细胞中,从而预防了酒精-吡唑肝炎中肝细胞损伤的发展。
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产品描述Malotilate, diisopropyl 1,3-dithiol-2-ylidenemalonate, is a drug used for the treatment of liver cirrhosis.(In Vitro):Malotilate reduces collagen synthesis and cell migration activity of fibroblasts in vitro.Malotilate, an anti-fibrotic substance, selectively inhibited the 5-lipoxygenase, whereas both the 12- and the 15-lipoxygenase pathways are stimulated. Malotilate has been shown to prevent acute experimental liver injury induced by several hepatotoxic compounds, including Ahyl alcohot, Bromobenzene, Carbon tetrachloride, ChIoroform, Dimethylnitrosamine and Thioacetamide.(In Vivo):Malotilate (100 mg/kg; p.o.; daily for 3 days) treatment in rats with hypocholesterolemia results in a rapid normalization of lowered serum cholesterol.
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体外实验Malotilate reduces collagen synthesis and cell migration activity of fibroblasts in vitro.Malotilate, an anti-fibrotic substance, selectively inhibited the 5-lipoxygenase, whereas both the 12- and the 15-lipoxygenase pathways are stimulated. Malotilate has been shown to prevent acute experimental liver injury induced by several hepatotoxic compounds, including Ahyl alcohot, Bromobenzene, Carbon tetrachloride, ChIoroform, Dimethylnitrosamine and Thioacetamide.
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体内实验Malotilate (100 mg/kg; p.o.; daily for 3 days) treatment in rats with hypocholesterolemia results in a rapid normalization of lowered serum cholesterol. Animal Model:Male rats of the SLC-SD strain (rats with carbon tetrachloride-induced liver damage)Dosage:100 mg/kg Administration:P.o.; daily for 3 days Result:The triglyceride secretion from livers in rats given CCI4 was inhibited to about 40% of the level in the control rats. This inhibition of the triglyceride secretion was completely normalized in response to malotilate administration for 3 days.
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同义词Malotilate | CL-1500 | NKK 105 | NKK-105
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通路Others
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靶点Other Targets
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受体Others
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研究领域Cancer
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适应症——
化学信息
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CAS Number59937-28-9
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分子量288.38
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分子式C12H16O4S2
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纯度>98% (HPLC)
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溶解度Ethanol: 58 mg/mL (201.12 mM); DMSO: 58 mg/mL (201.12 mM)
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SMILESO=C(OC(C)C)/C(C(OC(C)C)=O)=C1SC=CS/1
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化学全称1,3-Dithiol-2-ylidenepropanedioic acid, bis(1-methylethyl) ester
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Ohgoda O, et al. J Dermatol Sci, 1998, 17(2), 123-13