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Malotilate

CAS No. 59937-28-9

Malotilate ( Malotilate | CL-1500 | NKK 105 | NKK-105 )

产品货号. M15231 CAS No. 59937-28-9

Malotilate (NKK 105) 是一种口服活性的促肝药,是一种抗纤维化物质,可选择性抑制 5-lipoxygenase (5-LOX) (IC50=4.7 μM)。 Malotilate 通过降低肝脏乙醛水平并防止转铁蛋白保留在肝细胞中,从而预防了酒精-吡唑肝炎中肝细胞损伤的发展。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥365 有现货
10MG ¥583 有现货
25MG ¥737 有现货
50MG ¥988 有现货
100MG ¥1604 有现货
200MG ¥2090 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Malotilate
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Malotilate (NKK 105) 是一种口服活性的促肝药,是一种抗纤维化物质,可选择性抑制 5-lipoxygenase (5-LOX) (IC50=4.7 μM)。 Malotilate 通过降低肝脏乙醛水平并防止转铁蛋白保留在肝细胞中,从而预防了酒精-吡唑肝炎中肝细胞损伤的发展。
  • 产品描述
    Malotilate, diisopropyl 1,3-dithiol-2-ylidenemalonate, is a drug used for the treatment of liver cirrhosis.(In Vitro):Malotilate reduces collagen synthesis and cell migration activity of fibroblasts in vitro.Malotilate, an anti-fibrotic substance, selectively inhibited the 5-lipoxygenase, whereas both the 12- and the 15-lipoxygenase pathways are stimulated. Malotilate has been shown to prevent acute experimental liver injury induced by several hepatotoxic compounds, including Ahyl alcohot, Bromobenzene, Carbon tetrachloride, ChIoroform, Dimethylnitrosamine and Thioacetamide.(In Vivo):Malotilate (100 mg/kg; p.o.; daily for 3 days) treatment in rats with hypocholesterolemia results in a rapid normalization of lowered serum cholesterol.
  • 体外实验
    Malotilate reduces collagen synthesis and cell migration activity of fibroblasts in vitro.Malotilate, an anti-fibrotic substance, selectively inhibited the 5-lipoxygenase, whereas both the 12- and the 15-lipoxygenase pathways are stimulated. Malotilate has been shown to prevent acute experimental liver injury induced by several hepatotoxic compounds, including Ahyl alcohot, Bromobenzene, Carbon tetrachloride, ChIoroform, Dimethylnitrosamine and Thioacetamide.
  • 体内实验
    Malotilate (100 mg/kg; p.o.; daily for 3 days) treatment in rats with hypocholesterolemia results in a rapid normalization of lowered serum cholesterol. Animal Model:Male rats of the SLC-SD strain (rats with carbon tetrachloride-induced liver damage)Dosage:100 mg/kg Administration:P.o.; daily for 3 days Result:The triglyceride secretion from livers in rats given CCI4 was inhibited to about 40% of the level in the control rats. This inhibition of the triglyceride secretion was completely normalized in response to malotilate administration for 3 days.
  • 同义词
    Malotilate | CL-1500 | NKK 105 | NKK-105
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    Cancer
  • 适应症
    ——

化学信息

  • CAS Number
    59937-28-9
  • 分子量
    288.38
  • 分子式
    C12H16O4S2
  • 纯度
    >98% (HPLC)
  • 溶解度
    Ethanol: 58 mg/mL (201.12 mM); DMSO: 58 mg/mL (201.12 mM)
  • SMILES
    O=C(OC(C)C)/C(C(OC(C)C)=O)=C1SC=CS/1
  • 化学全称
    1,3-Dithiol-2-ylidenepropanedioic acid, bis(1-methylethyl) ester

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Ohgoda O, et al. J Dermatol Sci, 1998, 17(2), 123-13
产品手册
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