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Macozinone

CAS No. 1377239-83-2

Macozinone ( PBTZ169;PBTZ-169 )

产品货号. M11559 CAS No. 1377239-83-2

Macozinone (PBTZ-169, PBTZ169)is a potent, second-generation antituberculosis agent that inhibits DprE1 and displays nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥510 有现货
5MG ¥915 有现货
10MG ¥1458 有现货
25MG ¥2916 有现货
50MG ¥4520 有现货
100MG ¥6464 有现货
500MG ¥12879 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Macozinone
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Macozinone (PBTZ-169, PBTZ169)is a potent, second-generation antituberculosis agent that inhibits DprE1 and displays nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro.
  • 产品描述
    Macozinone (PBTZ-169, PBTZ169)is a potent, second-generation antituberculosis agent that inhibits DprE1 and displays nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro; PBTZ169 is less cytotoxic than BTZ043 and shows significantly better efficacy at lower concentrations in the murine model of chronic TB, inhibits DprE1 more efficiently than BTZ043.Bacterial Infection Phase 2 Clinical
  • 同义词
    PBTZ169;PBTZ-169
  • 通路
    GPCR/G Protein
  • 靶点
    Antibacterial
  • 受体
    DprE1
  • 研究领域
    Infection
  • 适应症
    Bacterial Infection

化学信息

  • CAS Number
    1377239-83-2
  • 分子量
    456.48
  • 分子式
    C20H23F3N4O3S
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO: 6.4 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    O=C1N=C(N2CCN(CC3CCCCC3)CC2)SC4=C([N+]([O-])=O)C=C(C(F)(F)F)C=C14
  • 化学全称
    2-[4-(cyclohexylmethyl)piperazin-1-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Makarov V, et al. EMBO Mol Med. 2014 Mar;6(3):372-83.
2. Makarov V, et al. Antimicrob Agents Chemother. 2015 Aug;59(8):4446-52.
3. González-Martínez NA, et al. PLoS Negl Trop Dis. 2015 Oct 16;9(10):e0004022.
4. Lechartier B, et al. Antimicrob Agents Chemother. 2015 Aug;59(8):4457-63.
产品手册
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