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Macozinone
CAS No. 1377239-83-2
Macozinone ( PBTZ169 | PBTZ-169 )
产品货号. M11559 CAS No. 1377239-83-2
Macozinone (PBTZ-169, PBTZ169) 是一种有效的第二代抗结核化合物，可抑制 DprE1，并在体外对结核分枝杆菌表现出纳摩尔级杀菌活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥510 | 有现货 |
|
| 5MG | ￥915 | 有现货 |
|
| 10MG | ￥1458 | 有现货 |
|
| 25MG | ￥2916 | 有现货 |
|
| 50MG | ￥4520 | 有现货 |
|
| 100MG | ￥6464 | 有现货 |
|
| 500MG | ￥12879 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Macozinone
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Macozinone (PBTZ-169, PBTZ169) 是一种有效的第二代抗结核化合物，可抑制 DprE1，并在体外对结核分枝杆菌表现出纳摩尔级杀菌活性。
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产品描述Macozinone (PBTZ-169, PBTZ169)?is a potent, second-generation antituberculosis agent that inhibits DprE1 and displays nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro; PBTZ169 is less cytotoxic than BTZ043 and shows significantly better efficacy at lower concentrations in the murine model of chronic TB, inhibits DprE1 more efficiently than BTZ043.Bacterial Infection Phase 2 Clinical(In Vitro):Macozinone (PBTZ169) is highly potent against M. tuberculosis in vitro, ex vivo, and in vivo.
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体外实验——
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体内实验——
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同义词PBTZ169 | PBTZ-169
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通路GPCR/G Protein
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靶点Antibacterial
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受体DprE1
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研究领域Infection
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适应症Bacterial Infection
化学信息
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CAS Number1377239-83-2
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分子量456.484
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分子式C20H23F3N4O3S
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纯度>98% (HPLC)
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溶解度DMSO: 6.4 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESO=C1N=C(N2CCN(CC3CCCCC3)CC2)SC4=C([N+]([O-])=O)C=C(C(F)(F)F)C=C14
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化学全称2-[4-(cyclohexylmethyl)piperazin-1-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Makarov V, et al. EMBO Mol Med. 2014 Mar;6(3):372-83.
2. Makarov V, et al. Antimicrob Agents Chemother. 2015 Aug;59(8):4446-52.
3. González-Martínez NA, et al. PLoS Negl Trop Dis. 2015 Oct 16;9(10):e0004022.
4. Lechartier B, et al. Antimicrob Agents Chemother. 2015 Aug;59(8):4457-63.
产品手册
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