MTOB

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MTOB 是 C 末端结合蛋白 (CtBP) 的底物，可干扰细胞培养物和小鼠中 CtBP 的致癌活性。它还积极调节 TCF-4 信号传导，导致癌症干细胞 (CSC) 生长和自我更新。

MTOB is a substrate for c-terminal binding protein (CtBP) that interferes with the carcinogenic activity of CtBP in cell culture and mice. It also actively regulates TCF-4 signaling, leading to cancer stem cell (CSC) growth and self-renewal.

MTOB sodium (10 mM) causes significant derepression (P<0.05) of 40% of CtBP target genes (including FGF9, CTNNB1, CEBPB, et al.) in MCF-7 and 46% in MBA-MD-231; increases the pro-epithelial E-cadherin/Vimentin ratio while reducing the pro-mesenchymal CD44/CD24 ratio, with a more significant trend (P<0.05) in MCF-7.

MTOB sodium (860 mg/kg; IP, at 1 h and 18 h after the first injury) effectively suppresses the increases duration of righting reflex, and significantly decreased neurological severity score (NSS) scores. Animal Model:C57BL/6 mice (traumatic brain injury)Dosage:860 mg/kg Administration:IP, at 1 h and 18 h after the first injuryResult:Effectively suppressed the increased duration of righting reflex, and significantly decreased NSS scores.

4-methylthio 2-oxobutyric acid | KMBA | MTOB salt | α-keto-γ-Methylthiobutyric acid

Others

Other Targets

Antiviral

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51828-97-8

170.16

C5H7NaO3S

>98% (HPLC)

In Vitro:?H2O : 125 mg/mL (734.60 mM)

[Na+].CSCCC(=O)C([O-])=O

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(-20℃)

With Ice Pack

≥ 2 years