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MSDC-0160
CAS No. 146062-49-9
MSDC-0160 ( PNU-91325;Mitoglitazone )
产品货号. M11984 CAS No. 146062-49-9
A new generation insulin sensitizer and mitochondrial target of thiazolidinediones (mTOT) modulator that has low affinity for binding and activation of PPARγ (EC50=23.7 uM).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥348 | 有现货 |
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| 5MG | ￥567 | 有现货 |
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| 10MG | ￥818 | 有现货 |
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| 25MG | ￥1264 | 有现货 |
|
| 50MG | ￥1677 | 有现货 |
|
| 100MG | ￥2989 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称MSDC-0160
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A new generation insulin sensitizer and mitochondrial target of thiazolidinediones (mTOT) modulator that has low affinity for binding and activation of PPARγ (EC50=23.7 uM).
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产品描述A new generation insulin sensitizer and mitochondrial target of thiazolidinediones (mTOT) modulator that has low affinity for binding and activation of PPARγ (EC50=23.7 uM) and shows insulin-sensitizing effects in mouse models of diabetes; increases AMPK activity and reduces mTOR activity, maintains β-cell phenotype in human islets.Diabetes Phase 2 Clinical
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同义词PNU-91325;Mitoglitazone
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通路Tyrosine Kinase
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靶点Insulin Receptor
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受体mTOT
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研究领域Metabolic Disease
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适应症Diabetes
化学信息
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CAS Number146062-49-9
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分子量370.42
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分子式C19H18N2O4S
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 30 mg/mL
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SMILESO=C(N1)SC(CC2=CC=C(OCC(C3=NC=C(CC)C=C3)=O)C=C2)C1=O
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化学全称2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
2. Bolten CW, et al. Gene Regul Syst Bio. 2007 Sep 17;1:73-82.
3. Rohatgi N, et al. PLoS One. 2013 May 1;8(5):e62012.
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Highly potent GIP receptor agonist (EC50 = 630 ± 119 pM). Displays equivalent cAMP stimulating properties and improved resistance to enzymatic degradation compared to native GIP in cells expressing wild type GIP receptor. Improves glucose tolerance, insulin release and cognitive function in various animal models of obesity and diabetes. Displays neuroprotective effects in an MPTP model of PD.
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