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首页- Products - Tyrosine Kinase - Insulin Receptor - MSDC-0160

MSDC-0160

CAS No. 146062-49-9

MSDC-0160 ( PNU-91325;Mitoglitazone )

产品货号. M11984 CAS No. 146062-49-9

A new generation insulin sensitizer and mitochondrial target of thiazolidinediones (mTOT) modulator that has low affinity for binding and activation of PPARγ (EC50=23.7 uM).

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ￥348 有现货
5MG ￥567 有现货
10MG ￥818 有现货
25MG ￥1264 有现货
50MG ￥1677 有现货
100MG ￥2989 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货
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生物学信息

  • 产品名称
    MSDC-0160
  • 注意事项
    本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
  • 产品简述
    A new generation insulin sensitizer and mitochondrial target of thiazolidinediones (mTOT) modulator that has low affinity for binding and activation of PPARγ (EC50=23.7 uM).
  • 产品描述
    A new generation insulin sensitizer and mitochondrial target of thiazolidinediones (mTOT) modulator that has low affinity for binding and activation of PPARγ (EC50=23.7 uM) and shows insulin-sensitizing effects in mouse models of diabetes; increases AMPK activity and reduces mTOR activity, maintains β-cell phenotype in human islets.Diabetes Phase 2 Clinical
  • 同义词
    PNU-91325;Mitoglitazone
  • 通路
    Tyrosine Kinase
  • 靶点
    Insulin Receptor
  • 受体
    mTOT
  • 研究领域
    Metabolic Disease
  • 适应症
    Diabetes

化学信息

  • CAS Number
    146062-49-9
  • 分子量
    370.42
  • 分子式
    C19H18N2O4S
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO: ≥ 30 mg/mL
  • SMILES
    O=C(N1)SC(CC2=CC=C(OCC(C3=NC=C(CC)C=C3)=O)C=C2)C1=O
  • 化学全称
    2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]-

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Colca JR, et al. Clin Pharmacol Ther. 2013 Apr;93(4):352-9.
2. Bolten CW, et al. Gene Regul Syst Bio. 2007 Sep 17;1:73-82.
3. Rohatgi N, et al. PLoS One. 2013 May 1;8(5):e62012.
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