MS-PPOH

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MS-PPOH 是一种有效的选择性细胞色素 P450 (CYP) 环氧化酶抑制剂。MS-PPOH 抑制 CYP2C8 和 CYP2C9，IC50 分别为 15 和 11 μM。MS-PPOH 是一种点击化学试剂。它含有 Alkyne 基团，可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。

MS-PPOH is a potent and selective cytochrome P450 (CYP) epoxygenase inhibitor. MS-PPOH inhibits CYP2C8 and CYP2C9 with IC50s of 15 and 11 μM, respectively. MS-PPOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

MS-PPOH blocks cellular EET synthesis. MS-PPOH inhibits tonic (basal) cell invasion and migration and reduces the 11,12-EET (1.0 μM)-induced cell motility.Cell Viability Assay Cell Line:PC-3 cells Concentration:2.0 and 10.0 μM Incubation Time:24 hours Result:Inhibited tonic (basal) cell invasion and migration.

MS-PPOH (20 mg/kg/day, i.v.) for 6 days significantly reduced renal levels of epoxyeicosatrienoic acids (EETs) in Dahl salt-resistant rats on 2% NaCl drinking solution.Animal Model:Six-week-old male stroke-prone spontaneously hypertensive rats (SHRSP)Dosage:20 mg/kg/day Administration:Intravenously Result:Treatment had negligible effects on systolic blood pressure (SBP) in saline-drinking SHRSP after 1 week, 160 vs. 167 mmHg, or 2 weeks of treatment, 171 vs. 175 mmHg, for vehicle vs. MS-PPOH, respectively.

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Metabolic Enzyme/Protease

P450

P450

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206052-02-0

323.41

C16H21NO4S

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 200 mg/mL (618.41 mM; 超声助溶 )

C(CCCCC(NS(C)(=O)=O)=O)C1=C(OCC#C)C=CC=C1

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(-20℃)

With Ice Pack

≥ 2 years