MS 15203

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MS15203 是一种有效的选择性 GPR171 激动剂。MS15203 增加食物摄入量和体重。MS15203 增加神经元活动。MS15203 显着增加了编码 proSAAS、NPY、AgRP 的 mRNA 的丰度。

MS15203 is a potent and selective GPR171 agonist. MS15203 increases food intake and body weight. MS15203 increases neuronal activity. MS15203 significantly increases the abundance of the mRNAs encoding proSAAS, NPY, AgRP.

MS15203 (MS0015203) dose-dependently increases [[35]S]GTPγS binding and inhibits adenylyl cyclase activity in rat hypothalamic membranes.

MS15203 (MS0015203) (3 mg/kg; i.p.) causes an increase in neuronal activity within cells containing GPR171 in the PVN..MS15203 (3 mg/kg; i.p.) significantly increases food intake at 4 and 8 hours.MS15203 (3 mg/kg; i.p.) significantly increases the abundance of the mRNAs encoding proSAAS, NPY, AgRP.

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Cell Cycle/DNA Damage

GPR

GPR

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73912-52-4

249.22

C12H11NO5

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 50 mg/mL (200.63 mM; 超声助溶 (<60°C)

O=C(O)C1=CC(=CC(=C1)C(=O)O)NC(=O)C(=C)C

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(-20℃)

With Ice Pack

≥ 2 years