MRT-10

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MRT 10 是一种平滑 (Smo) 受体拮抗剂（在瞬时表达小鼠 Smo 的 HEK293 细胞中，IC50 = 0.5 μM）。

MRT 10 is a smoothened (Smo) receptor antagonist (an IC50 = 0.5 μM in HEK293 cells transiently expressing mouse Smo). It also inhibits bodipy-cyclopamine binding to the murine Smo receptor (an IC50 = 0.5 μM.

MRT-10 inhibits the Smo-induced IP accumulation in a dosedependent manner (IC50=2.5 μM) in HEK293 cells.MRT-10 (10-9-10-5 M; 2 h) blocks Bodipy-cyclopamine (5 nM; 2 h) binding to cells expressing mouse Smo in a dosedependent manner with an IC50=0.5 μM.MRT-10 (10-9-10-5 M; 40 h) inhibits ShhN signaling in Shh-light2 cells in a dose-dependent manner with an IC50=0.64 μM.MRT-10 (10-9-10-5 M; 6 days) inhibits the SAG-induced (0.1 μM) alkaline phosphatase (AP) activity with an IC50=0.90 μM ) in C3H10T1/2 cells.

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MRT 10

GPCR/G Protein

Hedgehog (Hh)

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330829-30-6

465.52

C24H23N3O5S

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (214.81 mM)

COc1cc(cc(OC)c1OC)C(=O)NC(=S)Nc1cccc(NC(=O)c2ccccc2)c1

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(-20℃)

With Ice Pack

≥ 2 years