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首页- Products - Others - Other Targets - MRE-269

MRE-269

CAS No. 475085-57-5

MRE-269 ( MRE-269 | MRE269 | MRE 269 | ACT-333679 )

产品货号. M17517 CAS No. 475085-57-5

熊果酸属于熊果烷三萜家族，其结构基于五环熊果烷骨架。它具有作为 HIV-1 蛋白酶抑制剂的潜力。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ￥381 有现货
10MG ￥721 有现货
25MG ￥1158 有现货
50MG ￥1588 有现货
100MG ￥2673 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货
产品询价 大包装询价 加入购物车

生物学信息

  • 产品名称
    MRE-269
  • 注意事项
    本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
  • 产品简述
    熊果酸属于熊果烷三萜家族，其结构基于五环熊果烷骨架。它具有作为 HIV-1 蛋白酶抑制剂的潜力。
  • 产品描述
    MRE-269, also known as ACT-333679, is a long-acting and highly selective prostacyclin receptor agonist. MRE-269, the active form or metabolite of Selexipag (NS-304), is much more selective for the IP receptor than are the prostacyclin analogs beraprost and iloprost, which also have high affinity for the EP(3) receptor.
  • 体外实验
    MRE-269 induces endothelium-independent vasodilation of rat extralobar pulmonary artery (EPA). MRE-269 or other IP receptor agonists including epoprostenol, iloprost, treprostinil and beraprost increase cAMP levels in hPASMC. MRE-269 induces concentration-dependent vasodilation in LPA(+), LPA(-), and SPA(-).
  • 体内实验
    The vasorelaxant effects of MRE-269 on rat small intralobar pulmonary artery (SIPA) and EPA are the same, while the other IP receptor agonists induce less vasodilation in SIPA than in EPA. MRE-269 produces substantial relaxation of rat small pulmonary artery, although its effects are only significant at high concentrations of above 10 μM (pEC50, 4.98±0.22). By contrast, in rat small pulmonary veins, MRE-269 only produces minimal relaxation over the whole concentration range, with only significant relaxation occurring at the two highest doses of MRE-269 of 10 and 100 μM.
  • 同义词
    MRE-269 | MRE269 | MRE 269 | ACT-333679
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    HIV-1 protease
  • 研究领域
    Cardiovascular Disease
  • 适应症
    ——

化学信息

  • CAS Number
    475085-57-5
  • 分子量
    419.52
  • 分子式
    C25H29N3O3
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO : ≥ 50 mg/mL. 119.18 mM; H2O : < 0.1 mg/mL
  • SMILES
    CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(=O)C5(C)C)C)C)C2C1C)C)C(=O)O
  • 化学全称
    2-(4-((5,6-diphenylpyrazin-2-yl)(isopropyl)amino)butoxy)acetic acid

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

计算器

浓度计算器

摩尔计算器

分子量计算器

产品手册
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