
MRE-269
CAS No. 475085-57-5
MRE-269 ( MRE-269 | MRE269 | MRE 269 | ACT-333679 )
产品货号. M17517 CAS No. 475085-57-5
熊果酸属于熊果烷三萜家族,其结构基于五环熊果烷骨架。它具有作为 HIV-1 蛋白酶抑制剂的潜力。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥381 | 有现货 |
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10MG | ¥721 | 有现货 |
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25MG | ¥1158 | 有现货 |
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50MG | ¥1588 | 有现货 |
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100MG | ¥2673 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称MRE-269
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述熊果酸属于熊果烷三萜家族,其结构基于五环熊果烷骨架。它具有作为 HIV-1 蛋白酶抑制剂的潜力。
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产品描述MRE-269, also known as ACT-333679, is a long-acting and highly selective prostacyclin receptor agonist. MRE-269, the active form or metabolite of Selexipag (NS-304), is much more selective for the IP receptor than are the prostacyclin analogs beraprost and iloprost, which also have high affinity for the EP(3) receptor.
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体外实验MRE-269 induces endothelium-independent vasodilation of rat extralobar pulmonary artery (EPA). MRE-269 or other IP receptor agonists including epoprostenol, iloprost, treprostinil and beraprost increase cAMP levels in hPASMC. MRE-269 induces concentration-dependent vasodilation in LPA(+), LPA(-), and SPA(-).
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体内实验The vasorelaxant effects of MRE-269 on rat small intralobar pulmonary artery (SIPA) and EPA are the same, while the other IP receptor agonists induce less vasodilation in SIPA than in EPA. MRE-269 produces substantial relaxation of rat small pulmonary artery, although its effects are only significant at high concentrations of above 10 μM (pEC50, 4.98±0.22). By contrast, in rat small pulmonary veins, MRE-269 only produces minimal relaxation over the whole concentration range, with only significant relaxation occurring at the two highest doses of MRE-269 of 10 and 100 μM.
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同义词MRE-269 | MRE269 | MRE 269 | ACT-333679
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通路Others
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靶点Other Targets
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受体HIV-1 protease
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研究领域Cardiovascular Disease
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适应症——
化学信息
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CAS Number475085-57-5
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分子量419.52
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分子式C25H29N3O3
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纯度>98% (HPLC)
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溶解度DMSO : ≥ 50 mg/mL. 119.18 mM; H2O : < 0.1 mg/mL
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SMILESCC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(=O)C5(C)C)C)C)C2C1C)C)C(=O)O
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化学全称2-(4-((5,6-diphenylpyrazin-2-yl)(isopropyl)amino)butoxy)acetic acid
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
产品手册




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