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MP07-66

CAS No. 1938056-90-6

MP07-66 ( —— )

产品货号. M28875 CAS No. 1938056-90-6

MP07-66 is a novel FTY720-analog devoid of immunosuppressive effects leads to the reactivation of PP2A, which in turn triggers apoptosis of CLL cells.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥1725 有现货
10MG ¥2811 有现货
25MG ¥4771 有现货
50MG ¥6820 有现货
100MG ¥9396 有现货
500MG ¥18873 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    MP07-66
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    MP07-66 is a novel FTY720-analog devoid of immunosuppressive effects leads to the reactivation of PP2A, which in turn triggers apoptosis of CLL cells.
  • 产品描述
    MP07-66 is a novel FTY720-analog devoid of immunosuppressive effects leads to the reactivation of PP2A, which in turn triggers apoptosis of CLL cells.(In Vitro):CLL cells were incubated with increasing concentrations of MP07-66 (0-16 μM) for 24 and 48 hours and then subject to annexin V–PI flow cytometry. The level of apoptosis reached 50% and 80%, at 24 hours and 48 hours, respectively, at a MP07-66 concentration as high as 16 μM, which paralleled PARP cleavage, a marker of caspase-dependent apoptosis. In addition, the phosphorylation status of PP2A targets, namely Akt, GSK-3, and SHP-1, was negatively affected by the treatment with MP07-66, triggering known downstream events promoting apoptosis, such as Mcl-1 degradation and caspase-3 activation.
  • 同义词
    ——
  • 通路
    Metabolic Enzyme/Protease
  • 靶点
    Phosphatase
  • 受体
    PDE7
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    1938056-90-6
  • 分子量
    323.5
  • 分子式
    C19H33NO3
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    CCCCCCOc1ccc(CNCC(OCC)OCC)cc1
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.García AM, wt, al. Modulation of cAMP-specific PDE without emetogenic activity: new sulfide-like PDE7 inhibitors. J Med Chem. 2014 Oct 23;57(20):8590-607.
产品手册
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