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MN-64
CAS No. 92831-11-3
MN-64 ( MN-64 | MN 64 | MN64 )
产品货号. M17668 CAS No. 92831-11-3
MN-64 是一种端锚聚合酶抑制剂，对端锚聚合酶 、同工酶选择性和 Wnt 信号传导抑制具有 6 nM 的效力。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥316 | 有现货 |
|
| 10MG | ￥518 | 有现货 |
|
| 25MG | ￥1037 | 有现货 |
|
| 50MG | ￥1725 | 有现货 |
|
| 100MG | ￥2811 | 有现货 |
|
| 500MG | ￥6683 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称MN-64
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述MN-64 是一种端锚聚合酶抑制剂，对端锚聚合酶 、同工酶选择性和 Wnt 信号传导抑制具有 6 nM 的效力。
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产品描述MN-64 is a potent and selective inhibitor of Tankyrase 1 and 2 (IC50 = 6 and 72 nM, respectively). MN-64 blocks Wnt signaling in HEK293 cells containing a Wnt pathway reporter system. Tankyrases are ADP-ribosyltransferases that play key roles in various cellular pathways, including the regulation of cell proliferation, and thus, they are promising drug targets for the treatment of cancer.
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体外实验MN-64 is a potent tankyrase 1 inhibitor, with IC50s of 6 nM, 72 nM, 19.1 μM, 39.4 μM for TNKS1, TNKS2, ARTD1 and ARTD2, respectively. MN-64 effectively inhibits Wnt/β-catenin at 1 μM, and blocks STF luciferase activity at 200 nM.
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体内实验——
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同义词MN-64 | MN 64 | MN64
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通路Neuroscience
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靶点Gamma-secretase
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受体Tankyrase
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研究领域Cancer
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适应症——
化学信息
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CAS Number92831-11-3
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分子量264.32
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分子式C18H16O2
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纯度>98% (HPLC)
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溶解度DMSO : 100 mg/mL. 378.33 mM;
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SMILESCC(C)c1ccc(cc1)c1cc(=O)c2ccccc2o1
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化学全称2-[4-(1-Methylethyl)phenyl]-4H-1-benzopyran-4-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Narwal M, et al. J Med Chem. 2013 Oct 24;56(20):7880-9.
