MM3122

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MM3122 是一种选择性 II 型跨膜丝氨酸蛋白酶 (TMPRSS2) 抑制剂，IC50 = 0.34 nM。 MM3122 有效阻断 TMPRSS2，从而抑制 SARS-CoV-2 和 MERS-CoV 进入人体细胞。

MM3122 is a selective type II transmembrane serine protease (TMPRSS2) inhibitor, IC50 = 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells.(In Vitro):MM3122 (0-1 μM) has inhibitory activity against HGFA, matriptase, hepsin and thrombin with the IC50 values of 32, 0.31, 0.19 and more than 20 nM, respectively. MM3122 (0.1-100 μM) inhibits SARS-CoV-2 calu-3, MERS VSV pseudotype calu-3 and VSV-SARS CoV-2 chimera calu-3 with the EC50 values of 74, 0.87 nM and 0.43 respectively .(In Vivo):MM3122 (i.p., 0-100 mg/kg, daily, 7 days) has no adverse effects, no weight loss or changes in harvested organs (liver, spleen and kidney) compared to controls. MM3122 (i.p., 16.7 mg/kg, once) has a half-life of 8.6 hours in plasma and 7.5 hours in lung of NSG mice.

MM3122 (0-1 μM) has inhibitory activity against HGFA, matriptase, hepsin and thrombin with the IC50 values of 32, 0.31, 0.19 and more than 20 nM, respectively.MM3122 (0.1-100 μM) inhibits SARS-CoV-2 calu-3, VSV-SARS CoV-2 chimera calu-3 and MERS VSV pseudotype calu-3 with the EC50 values of 74, 0.43 and 0.87 nM, respectively.

MM3122 (i.p., 0-100 mg/kg, daily, 7 days) has no adverse effects, no weight loss or changes in harvested organs (liver, spleen and kidney) compared to controls in NOD-scid IL2Rgnull (NSG) mice.MM3122 (i.p., 16.7 mg/kg, once) has a half-life of 8.6 hours in plasma and 7.5 hours in lung of NSG mice.

Ac-GQFR-kbt | GTPL11533 | MM-3122

Others

Other Targets

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2574390-27-3

665.76

C31H39N9O6S

>98% (HPLC)

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C([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC(CNC(C)=O)=O)CCC(N)=O)=O)=O)CCCNC(=N)N)(=O)C2=NC=3C(S2)=CC=CC3

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(-20℃)

With Ice Pack

≥ 2 years