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MLS0315771

CAS No. 727664-91-7

MLS0315771 ( —— )

产品货号. M22503 CAS No. 727664-91-7

MLS0315771 is an effective and biologically active competitive phosphomannose isomerase (MPI) inhibitor (IC50: ~1 μM and a Ki: 1.4 μM).MLS0315771 is toxic to the zebrafish embryos above 2 μM. MLS0315771 toxicity at higher concentrations is an off-target effect.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥915 有现货
10MG ¥1393 有现货
25MG ¥2608 有现货
50MG ¥3467 有现货
100MG ¥4633 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    MLS0315771
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    MLS0315771 is an effective and biologically active competitive phosphomannose isomerase (MPI) inhibitor (IC50: ~1 μM and a Ki: 1.4 μM).MLS0315771 is toxic to the zebrafish embryos above 2 μM. MLS0315771 toxicity at higher concentrations is an off-target effect.
  • 产品描述
    MLS0315771 is an effective and biologically active competitive phosphomannose isomerase (MPI) inhibitor (IC50: ~1 μM and a Ki: 1.4 μM).MLS0315771 is toxic to the zebrafish embryos above 2 μM. MLS0315771 toxicity at higher concentrations is an off-target effect. MLS0315771 enhances mannose flux toward glycosylation. It ~50% of embryos appeared sick within 20 min at 8-10 μM, and most of them die by 30-60 min.
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    MPI
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    727664-91-7
  • 分子量
    273.33
  • 分子式
    C15H12FNOS
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    Cc1ccc(C)c(c1)-n1sc2cc(F)ccc2c1=O
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Sharma V, et al. Phosphomannose isomerase inhibitors improve N-glycosylation in selected phosphomannomutase-deficient fibroblasts. J Biol Chem. 2011 Nov 11;286(45):39431-8.
产品手册
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