MLS000532223

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MLS000532223 是一种选择性 Rho 家族 GTPases 抑制剂（EC50：16 μM 至 120 μM）。

MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM). MLS000532223, a general inhibitor that prevents GTP binding to several GTPases in a dose-dependent manner and is active in biochemical and cell-based secondary assays.?Live-cell imaging and confocal microscopy studies revealed the inhibitor-induced actin reorganization and cell morphology changes, characteristic of Rho GTPases inhibition.?

MLS000532223 prevents GTP binding to several GTPases in a dose-dependent manner.MLS000532223 modulates Rho-family GTP-binding kinetics.MLS000532223 is active in cell-based assays and inhibits EGF-stimulated Rac 1 activation.MLS000532223 inhibits actin rearrangements and changes in cell morphology that are downstream of Rho family GTPase activation.MLS000532223 (10 μM) modulates actin remodeling in mast cells.MLS000532223 (10 μM) inhibits ligand-stimulated β-hexosaminidase secretion of RBL cells.

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Others

Other Targets

Rho family GTPases

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16616-39-0

251.24

C15H9NO3

>98% (HPLC)

DMSO:45mg/ml (179.11 Mm; Need ultrasonic)

[O-][N+](=O)C1=CC=CC(=C1)C(=O)C#CC1=CC=CC=C1

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(-20℃)

With Ice Pack

≥ 2 years