ML355 ( ML355 | ML 355 | ML-355 )

产品货号. M17333 CAS No. 1532593-30-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

ML355
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

ML355是一种特异性、有效的12-脂氧合酶(12-LOX)抑制剂(IC50=0.34 μM)，具有良好的ADME特性。
产品描述

ML355 is a potent and selective inhibitor of human 12-lipoxygenase.
体外实验

ML355 inhibits PAR-4 induced aggregation and calcium mobilization in human platelets and reduce 12-HETE in β-cells.
体内实验

ML355 (1.88-30 mg/kg; i.g.; 2 times per day for two days) strongly inhibits the thrombus formation in mice at higher dose compared to WT controls. Animal Model:C57BL/6 mice Dosage:1.88, 3.75, 7.5, 15, 30 mg/kg Administration:Oral gavage; 2 times per day for two days Result:The thrombus formation in mice was strongly inhibited by higher doses of ML355.
同义词

ML355 | ML 355 | ML-355
通路

Others
靶点

Other Targets
受体

12-Lipoxygenase
研究领域

Inflammation/Immunology|Neurological Disease
适应症

——

CAS Number

1532593-30-8
分子量

441.52
分子式

C21H19N3O4S2
纯度

>98% (HPLC)
溶解度

DMSO : ≥ 42 mg/mL. 95.13 mM
SMILES

COC1=CC=CC(=C1O)CNC2=CC=C(C=C2)S(=O)(=O)NC3=NC4=CC=CC=C4S3
化学全称

N-2-benzothiazolyl-4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]-benzenesulfonamide

1.Luci DK, et al. J Med Chem. 2014 Jan 23;57(2):495-506.

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