
ML355
CAS No. 1532593-30-8
ML355 ( ML355 | ML 355 | ML-355 )
产品货号. M17333 CAS No. 1532593-30-8
ML355是一种特异性、有效的12-脂氧合酶(12-LOX)抑制剂(IC50=0.34 μM),具有良好的ADME特性。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥518 | 有现货 |
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5MG | ¥834 | 有现货 |
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10MG | ¥1320 | 有现货 |
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25MG | ¥2689 | 有现货 |
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50MG | ¥4447 | 有现货 |
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100MG | ¥6391 | 有现货 |
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500MG | ¥13203 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称ML355
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述ML355是一种特异性、有效的12-脂氧合酶(12-LOX)抑制剂(IC50=0.34 μM),具有良好的ADME特性。
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产品描述ML355 is a potent and selective inhibitor of human 12-lipoxygenase.
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体外实验ML355 inhibits PAR-4 induced aggregation and calcium mobilization in human platelets and reduce 12-HETE in β-cells.
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体内实验ML355 (1.88-30 mg/kg; i.g.; 2 times per day for two days) strongly inhibits the thrombus formation in mice at higher dose compared to WT controls. Animal Model:C57BL/6 mice Dosage:1.88, 3.75, 7.5, 15, 30 mg/kg Administration:Oral gavage; 2 times per day for two days Result:The thrombus formation in mice was strongly inhibited by higher doses of ML355.
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同义词ML355 | ML 355 | ML-355
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通路Others
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靶点Other Targets
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受体12-Lipoxygenase
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研究领域Inflammation/Immunology|Neurological Disease
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适应症——
化学信息
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CAS Number1532593-30-8
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分子量441.52
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分子式C21H19N3O4S2
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纯度>98% (HPLC)
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溶解度DMSO : ≥ 42 mg/mL. 95.13 mM
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SMILESCOC1=CC=CC(=C1O)CNC2=CC=C(C=C2)S(=O)(=O)NC3=NC4=CC=CC=C4S3
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化学全称N-2-benzothiazolyl-4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]-benzenesulfonamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Luci DK, et al. J Med Chem. 2014 Jan 23;57(2):495-506.
产品手册




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