ML297

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ML297 是一种选择性 Kir3.1/3.2 (GIRK1/2) 通道激活剂（GIRK1/2、GIRK1/4 和 GIRK1/3 的 IC50 值分别为 160、887 和 914 nM）。

ML297 is a selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively). ML297 exhibits no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels, and has minimal effect on a panel of other ion channels, receptors and transporters.

ML 297 is completely inactive for GIRK2/3.ML297 shows concentration-dependent efficacy in expressing GIRK1/2 cells and with an EC50 of 162 nM. ML297 shows a complete inability to modulate the activity of HEK-293 cells expressing GIRK2 alone and GIRKGIRK2/3.

ML297 (60 mg/kg; i.p.) shows a highly significant ability to both prevent convulsions and prevent fatality of the PTZ treatment. Animal Model:8-10 months old C57/BL6 male mice (approximately 30 g)Dosage:60 mg/kg Administration:Intraperitoneal injectionResult:Most of the animals neither convulsions nor death.

ML297 | ML 297 | ML-297

Others

Other Targets

GIRK1/2

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1443246-62-5

328.11

C17H14F2N4O

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (761.45 mM)

Fc1ccc(cc1F)NC(=O)Nc3cc(C)nn3c2ccccc2

1-(3,4-difluorophenyl)-3-(5-methyl-2-phenylpyrazol-3-yl)urea

(-20℃)

With Ice Pack

≥ 2 years