021-51111890
购物车（0）
sales@molnova.cn
MKK7-COV-3
CAS No. ——
MKK7-COV-3 ( MKK7 Covalen inhibitor 3 )
产品货号. M16994 CAS No. ——
MKK7-COV-3（MKK7 Covalen 抑制剂 3）是一种有效的、选择性的共价 MKK7 抑制剂，体外 IC50 为 5 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称MKK7-COV-3
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述MKK7-COV-3（MKK7 Covalen 抑制剂 3）是一种有效的、选择性的共价 MKK7 抑制剂，体外 IC50 为 5 nM。
-
产品描述MKK7-COV-3 (MKK7 Covalen inhibitor 3) is a potent, selective, covalent MKK7 inhibitor with in vitro IC50 of 5 nM, displays >1,000-fold selectivity over MKK4 (IC50=7.81 uM), shows EC50 of 1.3 uM for reduction of p-JNK in ICW assays in Beas2B cell line, without effect on p-ERK levels at 10 uM; displays remarkable selectivity against a kinome panel of 76 kinases, with very few kinases inhibited by more than 75% at 1 uM: Aurora kinase B, LRRK2, and MKK4, as well as FLT3; inhibits 60% of the CD86+ response in primary mouse B cells in response to LPS stimulation (10 μM, 2 hr pre-incubation).
-
体外实验——
-
体内实验——
-
同义词MKK7 Covalen inhibitor 3
-
通路MAPK/ERK Signaling
-
靶点MEK
-
受体MEK
-
研究领域——
-
适应症——
化学信息
-
CAS Number——
-
分子量277.327
-
分子式C17H15N3O
-
纯度>98% (HPLC)
-
溶解度——
-
SMILES——
-
化学全称N-(3-(6-methyl-1H-indazol-3-yl)phenyl)acrylamide
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Shraga A, et al. Cell Chem Biol. 2018 Oct 24. pii: S2451-9456(18)30344-1.
